An observational study in Cystic Fibrosis, sponsored by Bezmialem Vakif University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 6 Years to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-06.
Sponsored by Bezmialem Vakif University · Observational
Cystic fibrosis (CF) is a genetic disorder affecting exocrine glands, leading to thick, viscous secretions that damage organs such as the lungs, pancreas, and reproductive system. Respiratory failure from CF lung disease is a major cause of morbidity and mortality, with chronic inflammation and infections disrupting mucociliary clearance. This results in declining respiratory functions, muscle strength, physical inactivity, and quality of life. While some studies compare respiratory and lower extremity muscle endurance in children with CF, none have evaluated core muscle endurance. This study aims to compare respiratory muscle strength, endurance, and muscle endurance in the core and lower extremities between children with CF and healthy peers.
Cystic fibrosis (CF) is an autosomal recessive genetic disease characterized by the involvement of exocrine glands, resulting from a disorder in the synthesis or function of the Cystic Fibrosis Transmembrane Regulator (CFTR) protein. The CFTR protein is responsible for ion and water transport in the cell epithelium. Dysfunction of this protein causes the secretion produced to be deficient in water. Viscous secretion, which is difficult to remove from its environment, causes permanent damage to many organs and systems such as the lungs, pancreas, hepatobiliary system and reproductive system. Respiratory failure due to CF lung disease is the most important cause of morbidity and mortality. The basic mechanism in the pathophysiology of CF lung disease is chronic inflammation and recurrent infections that occur as a result of the disruption of mucociliary clearance by sticky secretions. This vicious cycle causes obstruction in the airways and leads to progressive losses in respiratory functions. The decrease in respiratory functions; loss of muscle strength, reduced functional capacity, physical inactivity and reduced quality of life. There are limited studies in the literature comparing the respiratory muscle strength, respiratory muscle endurance and lower extremity muscle endurance of children with CF with their healthy peers. However, there is no study evaluating the core muscle endurance of children with CF. This study aims to compare the respiratory muscle strength, respiratory muscle endurance, core muscle endurance and lower extremity muscle endurance in children with CF and their healthy peers.
1,581 studies on the registry are indexed under Cystic Fibrosis; 190 are open to participants now.
This study's enrollment of 48 is below the median of 85 across 482 observational studies indexed under Cystic Fibrosis.
Browse Cystic Fibrosis studies →Bezmialem Vakif University is the lead sponsor of 345 studies on the registry; 58 are open to participants now.
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Children diagnosed with cystic fibrosis and age matched healthy volunteers who do not have any diagnosed chronic diseases
Inclusion Criteria for Children with Cystic Fibrosis
Exclusion Criteria for Children with Cystic Fibrosis
Inclusion Criteria for Healthy Children
- Being between the ages of 6-18
Exclusion Criteria for Healthy Children
Children diagnosed cystic fibrosis
Other: Measurement of Core Muscle Endurance · Other: Respiratory Muscle Strength · Other: Respiratory Muscle Endurance · Other: Peripheral Muscle Endurance
Age-matched healthy volunteers
Other: Measurement of Core Muscle Endurance · Other: Respiratory Muscle Strength · Other: Respiratory Muscle Endurance · Other: Peripheral Muscle Endurance
Endurance of the flexor, extensor and lateral trunk muscles will be assessed using the McGill Trunk Endurance Tests.
Inspiratory and expiratory muscle strength will be made with a portable, electronic intra-oral pressure measuring device.
Respiratory muscle endurance testing will be measured using an inspiratory muscle training device at increasing threshold load.
Peripheral muscle endurance will be assessed by performing 30 and 60 second sit-to-stand tests.
Core muscles endurance
Endurance of the flexor, extensor and lateral trunk muscles will be assessed using the McGill Trunk Endurance Tests.
Time frame: Baseline
Respiratory Muscle Strength
Inspiratory and expiratory muscle strength will be made with a portable, electronic intra-oral pressure measuring device.
Time frame: Baseline
Respiratory muscle endurance
Respiratory muscle endurance testing will be measured using an inspiratory muscle training device at increasing threshold load.
Time frame: Baseline
Peripheral muscle endurance
Peripheral muscle endurance will be assessed by performing 30 and 60 second sit-to-stand tests.
Time frame: Baseline
Plan to share: No
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This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Bezmialem Vakif University