An interventional study of connective tissue graft and xenogenic collagen membrane in Dental and Implant, sponsored by Minia University. Completed at 1 site in Egypt. Open to participants aged 20 Years to 40 Years. Per ClinicalTrials.gov, last updated 2025-02-05.
Sponsored by Minia University · Not applicable, Interventional, and Prevention
This clinical trial aims to evaluate the effectiveness of the Modified Vascularized Interpositional Periosteal Connective Tissue Graft (mVIP-CTG) compared to Xenogeneic Collagen Matrix (XCM) around immediate implant in esthetic zone . This study will assess outcomes such as keratinized tissue thickness, keratinized tissue width, pink esthetic score and radiographic buccal cortex thickness over a defined follow-up period. By comparing mVIP-CTG to XCM, the study seeks to determine which method provides superior clinical and aesthetic results for best soft tissue augmentation
This study investigates two surgical techniques for managing peri-implant soft tissue deficiencies: the Modified Vascularized Interpositional Periosteal Connective Tissue Graft (VIP-CTG) and the Xenogeneic Collagen Matrix (XCM). Peri-implant soft tissue deficiencies, characterized by inadequate tissue volume or recession around dental implants, can lead to complications such as implant exposure, sensitivity, and aesthetic concerns. Conventional treatment methods aim to enhance soft tissue volume and improve the aesthetic and functional outcomes of implants.
The mVIP-CTG approach utilizes autogenous pedicle grafts to improve tissue thickness and width, potentially enhancing soft tissue integration and thickness around immediate implants. In contrast, XCM is a xenogenic membrane offering a minimally invasive alternative substitute for soft tissue regeneration.
The study design includes randomized assignment of participants to either the mVIP-CTG group or XCM group, with standardized surgical and follow-up protocols. Primary and secondary outcomes will include peri-implant soft tissue thickness, keratinized tissue width, pink esthetic score, and radiographic buccaal cortex thickness. Statistical analysis will evaluate the comparative effectiveness of both techniques in promoting peri-implant soft tissue regeneration and aesthetic recovery.
Minia University is the lead sponsor of 356 studies on the registry; 115 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria: -
Exclusion Criteria:
10 patients received pedicled CTG (mVIP-CTG)
Procedure: connective tissue graft
10 patients received xenogenic collagen membrane
Device: xenogenic collagen membrane
10 patients received mVIP-CTG
10 patients received XCM
keratinized tissue thickness
measurement of Kertinized tissue thickness around implant using endodontic file
Time frame: baseline, 3 months, 6 months
keratinized tissue width
measurement of keratinized tissue width using graduated UNC-15 Probe
Time frame: baseline, 3 months and 6 months
buccal cortex thickness
measurement of buccal cortex thickness using CBCT
Time frame: baseline and 6 months
pink esthetic score
measurement of pink aesthetic using visual scale of pink asethetic score
Time frame: baseline and 6 months
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This study is completed, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.
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Minia University