An observational study in Pregnancy Rate IVF and Blastocyst IVF, sponsored by Calla IVF Center. Completed at 1 site in Romania. Open to female participants aged 21 Years to 40 Years. Per ClinicalTrials.gov, last updated 2025-01-28.
Sponsored by Calla IVF Center · Observational
This prospective observational study was conducted over 12 months and involved 80 IVF patients aged 20-40 years. Patients were divided into two groups based on KIR genotype (KIR AA and non-KIR AA). Endometrial biopsies were collected during the mid-luteal phase for immunohistochemical analysis of CD56+ NK cell levels. Statistical analyses, including logistic regression and ROC curve evaluation, assessed the relationship between CD56 levels, KIR genotype, and implantation success.
Calla IVF Center is the lead sponsor of 4 studies on the registry; none are open to participants now.
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A total of 80 patients were included, with 40 in each group (KIR AA and non-KIR AA). All participants provided written informed consent, and the study protocol was approved by the institutional ethics committee.
Exclusion Criteria:
In any pregnancy, the maternal KIR genotype could be AA (mostly inhibitory KIRs), AB, or BB (mostly activating KIRs). A KIR AA haplotype is defined as cen-A and tel-A
Other: Establishing the correlation between KIR AA and KIR non-AA and CD56 endometrial cells and IVF succes
In any pregnancy, the maternal KIR genotype could be AA (mostly inhibitory KIRs), AB, or BB (mostly activating KIRs). KIR Bb haplotype is described as cenB/telB, cenA/telB, or cenB/telA
Other: Establishing the correlation between KIR AA and KIR non-AA and CD56 endometrial cells and IVF succes
The analysis aimed to compare CD56 levels between patients with the KIR AA genotype and those without. A multiple linear regression model was used to determine the predictive value of CD56+ levels, KIR genotype, and age on the number of blastocysts.
the relationship between endometrial CD56+ NK cells, KIR AA genotypes, and IVF success.
The value of CD56 NK cell and KIR AA in patients undergoing IVF and pregnancy rate
Time frame: 12 months
This study is completed, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.
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