An interventional study of Lower limb resistance training and Upper limb resistance training in Local Hypoalgesia, Distal Hypoalgesia and Resistance Training, sponsored by Centro Universitario La Salle. Recruiting at 1 site in Spain. Open to participants aged 18 Years to 64 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-02-26.
Sponsored by Centro Universitario La Salle · Not applicable, Interventional, and Treatment
This randomized controlled trial with healthy subjects aims to compare exercise-induced hypoalgesia among three groups: one utilizing a lower limb resistance training intervention, another using an upper limb resistance training, and a control group. The exercise protocol involves 3 sets of 5 repetitions of resistance exercises (brachial biceps curl and leg extensions). Exercise-induced hypoalgesia will be assessed by measuring pressure pain thresholds in the thigh and elbow, comparing exercise interventions with the control group. Additionally, a secondary objective is to compare the lower limb and upper limb resistance training groups in terms of their effects on pressure pain thresholds in the thigh and elbow. Thus, the study anticipates observing differences in local and distal hypoalgesia based on the trained region.
10,054 studies on the registry are indexed under Pain; 1,649 are open to participants now.
This study's planned enrollment of 90 is above the median of 66 across 8,493 interventional studies indexed under Pain.
Browse Pain studies →Centro Universitario La Salle is the lead sponsor of 25 studies on the registry; 7 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
The participants in the lower limb resistance training group will undergo 3 sets of 5 repetitions of leg extensions with the 5-resistance maximum (5RM), comprising a 5-minute warm-up in cycle ergometer at 1 watt per kg and 60-80 revolutions per minute and 1 set of 5 repetitions with the 10-resistance maximum (10RM).
Other: Lower limb resistance training
The participants in the upper limb resistance training group will undergo 3 sets of 5 repetitions of brachial biceps curl with the 5RM, comprising a 5-minute warm-up in cycle ergometer at 1 watt per kg and 60-80 revolutions per minute and 1 set of 5 repetitions with the 10RM.
Other: Upper limb resistance training
Participants in the control group will remain seated for the entire duration of the experiment without receiving any form of distraction.
Exercise intervention with leg extensions on the dominant quadriceps, doing 3 sets of 5 repetitions with the 5RM after a 5-minute warm-up with a cycle ergometer at 1 watt per kg and 60-80 revolutions per minute and 1 set of 5 repetitions with the 10RM. Previously, 72 hours before, the 5RM would have been calculated progressively approaching in sets of 5 repetitions, starting with the lower weight and stopping the test when obtaining an unsuccessful trial (the participant could not manage to lift the weight five times). The previous successful set would be established as the 5RM.
Exercise intervention with brachial biceps curl on the dominant brachial biceps, doing 3 sets of 5 repetitions with the 5RM after a 5-minute warm-up with a cycle ergometer at 1 watt per kg and 60-80 revolutions per minute and 1 set of 5 repetitions with the 10RM. Previously, 72 hours before, the 5RM would have been calculated progressively approaching in sets of 5 repetitions, starting with the lower weight and stopping the test when obtaining an unsuccessful trial (the participant could not manage to lift the weight five times). The previous successful set would be established as the 5RM.
Pain pressure threshold (PPT) on dominant quadriceps and dominant brachial biceps
PPT is tested on the muscle belly of the quadriceps on the dominant side, at half of the distance between the anterior-superior iliac spine and the superior pole of the patella, and on the muscle belly of the brachial biceps on the dominant side, at a point one-fourth of the distance from the elbow crease to the lateral border of the acromion. The region to be pressed is marked with a pen. The patient is instructed to report the first appearance of the sensation of "discomfort". An ascending ramp of 0.5 kg/cm/s is applied, at the rhythm of a metronome. The instrument measures 0 to 25 kg, with a higher score interpreted as a hypoalgesia response. The measurement is started on the quadriceps and alternated with the biceps until 3 measurements of each region are obtained. Each measurement in the same region is obtained after 30 seconds of rest. This protocol has demonstrated high inter-observer reliability measuring healthy subjects (ICC = 0.91).
Time frame: before, immediately after intervention, and 30 minutes after intervention.
International Physical Activity Questionnaire (IPAQ)
7-item questionnaire on the level of physical activity at different intensities (high, moderate, and low) and hours sitting. A higher score means higher weekly physical activity
Time frame: before intervention (up 5 minutes)
Physical Activity Readiness Questionnaire (PAR-Q)
7-item questionnaire that assesses an individual's readiness to engage in physical activity based on whether any known contraindications have been ruled out by the participant. If all the questions are negative, the participant can safely engage in a physical activity.
Time frame: before intervention (up 5 minutes)
Fatigue Assessment Scale (FAS)
10-item questionnaire that allows for the evaluation of the participant's current level of fatigue. This instrument measures 10 to 50 points. A higher score means higher fatigue.
Time frame: before intervention (up 5 minutes)
Rate of perceived exertion (RPE)
RPE Borg CR-10 is used to measure how hard your body works during physical activity. It runs from 0 - 10, using numbers to rate how much effort an activity takes. Higher scores indicate a higher perception of effort.
Time frame: immediately after intervention (up 10 seconds)
Plan to share: No
No publications or documents are linked to this record.
Started Feb 2025 (actual). Primary completion is estimated for May 2025, 3 months after the start.
Of 3,731 non-industry interventional studies with no phase under Pain, half reached primary completion within 10 months of starting (the median), counting those still running; a quarter within 4 and three quarters within 23. This study's planned 3 months is below that.
Counting every sponsor, half of 3,830 studies reached it within 10 months; a quarter within 4 and three quarters within 23.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Centro Universitario La Salle