An interventional study of inspiratory muscle training and acupucnture like transcutanoeus electrical nerve stimulation and inspiratory muscle training in Sickle Cell Disease, sponsored by Cairo University. Recruiting at 1 site in Egypt. Open to participants aged 20 Years to 50 Years. Per ClinicalTrials.gov, last updated 2025-01-03.
Sponsored by Cairo University · Not applicable, Interventional, and Prevention
pulmonary complications are common in sickle cell disease patients. Respiratory training using inspiratory muscle trainer (IMT) is usually a good choice to improve these complications. Recently, acupuncture like transcutaneous electrical nerve stimulation (AC-tens) may also improve these complications.
sickle cell disease patients whose number will be forty patients will be divided to group I who will trained with IMT (threshold inspiratory muscle training) and treated with AC-tens (the number of patients will be 20) or group II who will trained with IMT (the number of patients will be 20) . The number of sessions per week will be three sessions for IMT or AC-tens for 12 weeks. the IMT will be performed for six sets of respiratory training cycles and the set will contain 10 respiratory cycles. Also the session of AC-tens will be 45 minute on bilateral Ex-B1 acupoint. the parameters of AC-tens will be four hertz and 200 microsecond pulse duration.
1,103 studies on the registry are indexed under Anemia, Sickle Cell; 235 are open to participants now.
This study's planned enrollment of 40 is close to the median of 40 across 750 interventional studies indexed under Anemia, Sickle Cell.
Browse Anemia, Sickle Cell studies →Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.
Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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Exclusion Criteria:
sickle cell disease patients whose number will be 20 patients will be trained with IMT (threshold inspiratory muscle training) and treated with AC-tens. The number of sessions per week will be three sessions for IMT or AC-tens for 12 weeks. the IMT will be performed for six sets of respiratory training cycles and the set will contain 10 respiratory cycles. Also the session of AC-tens will be 45 minute on bilateral Ex-B1 acupoint. the parameters of AC-tens will be four hertz and 200 microsecond pulse duration.
Behavioral: inspiratory muscle training and acupucnture like transcutanoeus electrical nerve stimulation
sickle cell disease patients whose number will be 20 patients who will trained with IMT (threshold inspiratory muscle training). The number of sessions per week will be three sessions for IMT for 12 weeks. the IMT will be performed for six sets of respiratory training cycles and the set will contain 10 respiratory cycles.
Behavioral: inspiratory muscle training
sickle cell disease patients whose number will be 20 patients will be trained with IMT (threshold inspiratory muscle training) and treated with AC-tens. The number of sessions per week will be three sessions for IMT or AC-tens for 12 weeks. the IMT will be performed for six sets of respiratory training cycles and the set will contain 10 respiratory cycles. Also the session of AC-tens will be 45 minute on bilateral Ex-B1 acupoint. the parameters of AC-tens will be four hertz and 200 microsecond pulse duration.
sickle cell disease patients whose number will be 20 patients who will trained with IMT (threshold inspiratory muscle training). The number of sessions per week will be three sessions for IMT for 12 weeks. the IMT will be performed for six sets of respiratory training cycles and the set will contain 10 respiratory cycles.
FEV1/FVC ratio
will be measured by spirometry
Time frame: it will be assessed after12 weeks
forced expiratory volume at the first second of expiration
will be measured by spirometry
Time frame: it will be assessed after12 weeks
forced vital capacity
will be measured by spirometry
Time frame: it will be assessed after12 weeks
six minute walk distance
it will be a measure of physical capacity
Time frame: it will be assessed after12 weeks
physical summary of short form 36
it is a questionnaire measure of quality of life
Time frame: it will be assessed after12 weeks
mental summary of short form 36
it is a questionnaire measure of quality of life
Time frame: it will be assessed after12 weeks
right diaphragmatic excrusion
it will be assessed by ultrasonography
Time frame: it will be measured after 12 weeks
left diaphragmatic excrusion
it will be assessed by ultrasonography
Time frame: it will be measured after 12 weeks
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Cairo University