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CompletedNCT06756594Updated May 27, 2026

Efficacy of Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation

An interventional study of Dexmedetomidine-Propofol and Ketamine-Propofol in Propofol, sponsored by Sohag University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-05-27.

Sponsored by Sohag University · Not applicable, Interventional, and Screening

Phase
Not applicable
Study type
Interventional
Enrollment
100
Allocation
Randomized
Ages
18 Years to 60 Years
Sex
All
01

Study summary

This study aims to compare efficacy of sedation between Dexmedetomidine-Propofol and Ketamine-Propofol combinations in the upper or lower gastrointestinal system endoscopy. We compare between 2 combinations as regard hemodynamic stability, post operative side effects as occurrence of delirium, nausea, vomiting, headache, hallucination or agitation.

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Conditions studied

  • Propofol
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In context

Lead sponsor

Sohag University is the lead sponsor of 1,183 studies on the registry; 612 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • American Society of Anesthesiologists physical status I to II.
  • Age between 18 and 60 years.
  • Both sexes.

Exclusion criteria

Exclusion Criteria:

  • Having severe heart, lung, liver disease, kidney failure, or bleeding disorder.
  • Patients having fever, hypothermia or infection, electrolyte disorders, such as hypokalemia and hypocalcaemia, acid-base disorder, allergy to drugs to be used.
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Study design

Phase
Not applicable
Primary purpose
Screening
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
100 participants (actual)

Study arms

  • Active comparator
    Dexmedetomidine-Propofol for sedation during gastrointestinal endoscopy

    efficacy of sedation with Dexmedetomidine-Propofol combination in the upper or lower gastrointestinal system endoscopy.

    Drug: Dexmedetomidine-Propofol

  • Active comparator
    Ketamine-Propofol for sedation during gastrointestinal endoscopy

    efficacy of sedation with Ketamine-Propofol combination in the upper or lower gastrointestinal system endoscopy.

    Drug: Ketamine-Propofol

Interventions

  • DrugDexmedetomidine-Propofol

    efficacy of sedation with Dexmedetomidine-Propofol combination in the upper or lower gastrointestinal system endoscopy.

  • DrugKetamine-Propofol

    efficacy of sedation with Ketamine-Propofol combination in the upper or lower gastrointestinal system endoscopy.

06

What researchers measure

Primary outcomes

  1. intraoperative and postoperative monitoring of sedation during upper or lower gastrointestinal system endoscopy.

    Sedation level

    Time frame: every 5 minutes intraoperative and every 15 minutes for 2 hours postoperative.

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Study locations

1 site
  • Sohag University Hospital
    Sohag, Egypt
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References and documents

Publications

  • Tekeli AE, Oguz AK, Tuncdemir YE, Almali N. Comparison of dexmedetomidine-propofol and ketamine-propofol administration during sedation-guided upper gastrointestinal system endoscopy. Medicine (Baltimore). 2020 Dec 4;99(49):e23317. doi: 10.1097/MD.0000000000023317. PubMed 33285707 ↗
  • Zhang F, Sun HR, Zheng ZB, Liao R, Liu J. Dexmedetomidine versus midazolam for sedation during endoscopy: A meta-analysis. Exp Ther Med. 2016 Jun;11(6):2519-2524. doi: 10.3892/etm.2016.3186. Epub 2016 Mar 24. PubMed 27284342 ↗
  • Chang ET, Certal V, Song SA, Zaghi S, Carrasco-Llatas M, Torre C, Capasso R, Camacho M. Dexmedetomidine versus propofol during drug-induced sleep endoscopy and sedation: a systematic review. Sleep Breath. 2017 Sep;21(3):727-735. doi: 10.1007/s11325-017-1465-x. Epub 2017 Jan 27. PubMed 28130737 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 27, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06756594
Lead sponsor
Sohag University
Responsible party
Ahmed Hany Hamed (Resident, Department of Anesthesia, Intensive Care and Pain management, Faculty of Medicine, Sohag University, Sohag University) — Principal investigator
First posted
Jan 3, 2025
Start date
Nov 12, 2024
Primary completion
Jun 11, 2025
Completion
Jun 11, 2025
Last update
May 27, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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