An interventional study of carbohydrate electrolyte drink and no-sugar electrolyte drink in Dehydration and Dehydration Related to Exercise, sponsored by Arizona State University. Completed at 1 site in United States. Open to participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-27.
Sponsored by Arizona State University · Not applicable, Interventional, and Basic science
Caffeine is known to enhance physical and mental performance, but few beverages combine caffeine with electrolytes and carbohydrates to enhance exercise performance. This study evaluates a caffeinated electrolyte-glucose drink's effect on endurance, strength, and cognition. Using a repeated-measures, cross-over design, 20 trained cyclists will complete one familiarization and four randomized 3-hour experimental trials (Liquid I.V.™ Energy Multiplier, Hydration Multiplier, Sugar-Free Hydration Multiplier, and water). Each trial includes 2 hours of cycling in a warm environment (32ºC), followed by strength and cognitive assessments. Cycling performance, capillary blood, urine, and expiratory gases will be collected.
Each subject will complete 5 trials (1 familiarization and 4 experimental) consisting of approximately 2 hours cycling in a warm environment (90ºF), followed by strength assessment and cognitive assessment via questionnaire. Each trial will be identical, with the only difference being the type of drink consumed during each trial. The first trial will be for familiarization without any blood sampling. The rest of the trials will be completed in a randomized order and the drink consumed
Cycling Endurance Exercise Performance
The exercise test will consist of a series of three consecutive cycling sets in a warm environment (90ºF), with each series consisting of:
At regular intervals throughout the exercise task, body weight, blood samples, respiratory gasses, and perceptual data will be collected. See study schematic provided below for specific measurement timepoints.
Upon completion of the cycling task subjects will moved to another room with cool temperature (70ºF), where strength and cognitive function will be assessed to determine the influence of each beverage on indices of exercise performance and fatigue.
201 studies on the registry are indexed under Dehydration; 28 are open to participants now.
This study's enrollment of 26 is below the median of 43 across 145 interventional studies indexed under Dehydration.
Browse Dehydration studies →Arizona State University is the lead sponsor of 238 studies on the registry; 42 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
History of caffeine sensitivity
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Water masked with non-caloric and no-sodium
Dietary Supplement: Water (Placebo)
2% carbohydrate solution with 1,020 mg/L of Sodium
Dietary Supplement: carbohydrate electrolyte drink
1% carbohydrate solution with 1,060 mg/L of Sodium
Dietary Supplement: no-sugar electrolyte drink
1% carbohydrate solution with 1,000 mg/L of Sodium, and 200mg/L Caffeine
Dietary Supplement: Caffeinated Carbohydrate and electrolyte drink
2% carbohydrate solution with 1,020 mg/L of Sodium
1% carbohydrate solution with 1,060 mg/L of Sodium
2% carbohydrate solution with 1,000 mg/L of Sodium, and 200mg/L caffeine
flavored water with non-caloric, non-sodium-containing sweetner
5 kilometer cycling time trial
Time in minutes of completion the 5 kilometer cycling time trial at the 3rd exercise bout.
Time frame: During the 3rd time trial which is the last time trial.
5 kilometer Time trial performance
Time to completion the 2nd cycling time trial
Time frame: 2nd time trial
Isokinetic stregth
Peak torque at 60º/sec at dominant knee during extension
Time frame: right after the cycling tests
Congitive performance 1
Attention Network Test score
Time frame: after the completion of strength test
Cognitive performance 2
Working Memory Test score
Time frame: after the end of the strength assessment
Congitive test 3
Stroop Task score
Time frame: right after the strength test
Blood glucose
Blood glucose levels during the 3rd cycling time trial.
Time frame: at the end of the 3rd cycling time trial.
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.