An observational study in Lung Cancer, Solid Pulmonary Nodules and Pulmonary Nodules, sponsored by The Third Affiliated Hospital of Kunming Medical College.. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-11-12.
Sponsored by The Third Affiliated Hospital of Kunming Medical College. · Observational
Study Objective:
To comprehensively analyze the preoperative clinical and imaging characteristics of solid pulmonary nodules, investigate the risk factors associated with malignant solid pulmonary nodules, and provide a reference for preoperative treatment decisions.
Significance of the Study:
According to the 2020 Global Cancer Report, lung cancer remains the leading cause of cancer-related deaths worldwide. While the majority of patients with stage I lung cancer achieve long-term survival, survival rates for advanced-stage patients are extremely low. Early screening, diagnosis, and treatment of lung cancer are crucial.
With the widespread implementation of early lung cancer screening, a growing number of pulmonary nodules are being detected, among which solid pulmonary nodules constitute a significant proportion. Unlike ground-glass nodules, accurately distinguishing between benign and malignant solid nodules is critical for determining appropriate treatment strategies. For benign solid nodules, follow-up observation is the preferred approach, whereas early surgical intervention is essential for malignant solid nodules.
Although previous studies have explored the correlation between clinical and imaging characteristics, they have not conducted systematic analyses, and most have been based on small sample sizes. Therefore, this study aims to conduct a comprehensive analysis of preoperative clinical and imaging characteristics, build a predictive model to differentiate between benign and malignant solid pulmonary nodules, and provide a reliable reference for selecting treatment strategies.
Our study evaluate patients with SPN from the Third Affiliated Hospital of Kunming Medical University. The patient selection followed specific inclusion and exclusion criteria. Inclusion criteria included: (1) All subjects provided CT imaging obtained from the Third Affiliated Hospital of Kunming Medical University within 2-week period prior to surgery; (2) Complete clinicopathological data of solid nodules were obtained; (3) Surgical intervention for one or more SPN; (4) No prior anti-tumor treatments like radiotherapy or chemotherapy; (5) Age 18 years or older. Exclusion criteria involved: (1) Patients with incomplete imaging data or medical records; (2) Lung infections that could affect image analysis; (3) Significant respiratory movement artifacts in images impairing imaging analysis; (4) Inconsistent locations of SPN in postoperative pathology reports and preoperative CT images.
5,422 studies on the registry are indexed under Lung Neoplasms; 1,346 are open to participants now.
This study's planned enrollment of 320 is above the median of 200 across 1,434 observational studies indexed under Lung Neoplasms.
Browse Lung Neoplasms studies →The Third Affiliated Hospital of Kunming Medical College. is the lead sponsor of 2 studies on the registry; 2 are open to participants now.
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The study population includes patients aged 18 years and older with radiologically diagnosed solid pulmonary nodules. These patients are undergoing preoperative clinical and imaging evaluations and subsequent surgical resection to confirm the benign or malignant nature of the nodules
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Exclusion Criteria:
Participants with benign solid pulmonary nodules.
Other: Preoperative Clinical and Imaging Feature Evaluation for Predictive Modeling
Participants with malignant solid pulmonary nodules.
Other: Preoperative Clinical and Imaging Feature Evaluation for Predictive Modeling
This study involves preoperative evaluation of clinical and imaging features for constructing a predictive model to differentiate benign and malignant solid pulmonary nodules. Surgical resection is performed to obtain pathological confirmation as the reference standard.
Diagnostic performance of predictive model
The primary outcome is the area under the receiver operating characteristic curve (AUC) of the predictive model in distinguishing benign from malignant solid pulmonary nodules, based on preoperative clinical and imaging features.
Time frame: Within 2 years after surgical resection and pathological confirmation
No study locations are listed for this record.
Plan to share: No — The datasets generated and/or analyzed during the current study are not publicly available due sharing data is not included in our research institution review board.
Start is estimated for Nov 2024; primary completion for Jan 2025, 2 months later.
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This study is not yet recruiting, as verified in Nov 2024. You cannot join it, but the record below documents what was studied.
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The Third Affiliated Hospital of Kunming Medical College.