An observational study in Liver Injury and Liver Injury, Drug-Induced, sponsored by Drug Induced Liver Disease Study Group. Active, not recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-05-04.
Sponsored by Drug Induced Liver Disease Study Group · Observational
This is an open-enrollment, retrospective, observational study without interventions. Its primary objective is to understand 1) incidence of liver injury among all the hospitalized patient from participating centers after the administration of immune checkpoint inhibitors or molecularly targeted agents; 2) epidemiologic and clinical characteristics of liver injury, including suspected medications, clinical types, histological characteristics, severity, treatment and outcomes.
75 studies on the registry are indexed under Chemical and Drug Induced Liver Injury; 20 are open to participants now.
This study's planned enrollment of 2,000 is above the median of 504 across 38 observational studies indexed under Chemical and Drug Induced Liver Injury.
Browse Chemical and Drug Induced Liver Injury studies →Drug Induced Liver Disease Study Group is the lead sponsor of 6 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
All hospitalized patients from participating medical centers.
Exclusion Criteria:
Change in ALT (alanine aminotransferase)
Absolute change
Time frame: on day 10
Proportion of patients with normalized liver biochemistry
Count of subjects
Time frame: on day 3, 7, 10, 14, 21, and 30
Change in liver biochemistry
Absolute change
Time frame: on day 3, 7, 10, 14, 21, and 30
Time to normalization of liver biochemistry
Days
Time frame: up to 6 month
Proportion of patients with ≥ 50% reduction in liver biochemistry
Count of subjects
Time frame: on day 3, 7, 10, 14, 21, and 30
This study is active, not recruiting, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.
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Chemical and Drug Induced Liver Injury→
Drug Induced Liver Disease Study Group