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CompletedNCT06665425Updated Apr 20, 2026

PK,PD and DDI of Epaminurad and C2406 in Healthy Volunteers

A Phase 1 interventional study of Epaminurad 9 mg and C2406 in Healthy Volunteers, sponsored by JW Pharmaceutical. Completed at 1 site in South Korea. Open to participants aged 19 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-20.

Sponsored by JW Pharmaceutical · Phase 1, Interventional, and Treatment

Phase
Phase 1
Study type
Interventional
Enrollment
18
Allocation
Not applicable
Ages
19 Years to 50 Years
Sex
All
01

Study summary

A Phase 1 Study to evaluate the safety, PK/PD, drug-drug interaction(DDI) of Epaminurad and C2406 in Healthy Volunteers

02

Conditions studied

  • Healthy Volunteers
03

In context

Lead sponsor

JW Pharmaceutical is the lead sponsor of 75 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
19 Years to 50 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  1. Age: 19\~50
  2. Weight: between 50.0 kg\~90.0 kg, Body Mass Index(BMI): 18.0 kg/m\^2 or heavier and below 30.0 kg/m\^2

Exclusion criteria

Exclusion Criteria:

  1. Medical history- chronic liver disease, acute gout attack, uric acid stone, diabetes, hypertension, hyperlipidemia or lipid abnormality
  2. Clinical examination

    • eGFR (CKD-EPI) \< 90mL/min/1.73m\^2
    • Serum uric acid \< 3 mg/dL or > 7 mg/dL
    • AST (SGOT), ALT (SGPT) > upper limit of normal ranges X 1.5
    • Total bilirubin, γ-GTP > upper limit of normal ranges X 1.5
    • CK > upper limit of normal ranges X 2
    • Positive serologic results
05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
18 participants (actual)

Study arms

  • Experimental
    Arm 1

    Epaminurad 9mg, C2406 0.6mg

    Drug: Epaminurad 9 mg · Drug: C2406

Interventions

  • DrugEpaminurad 9 mg

    Period 1: Epaminurad / Period 2: C2406 -\> Epaminurad + C2406

  • DrugC2406

    Period 1: Epaminurad / Period 2: C2406 -\> Epaminurad + C2406

06

What researchers measure

Primary outcomes

  1. Area under the plasma concentration versus time curve (AUC)

    To evaluate the AUC of Epaminurad and C2406

    Time frame: 7 days

  2. Peak plasma concentrations (Cmax)

    To evaluate the Cmax of Epaminurad and C2406

    Time frame: 7 days

07

Study locations

1 site
  • Seoul National University Hospital Clinical Trials Center
    Seoul, Seoul 110-744, South Korea
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 20, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06665425
Lead sponsor
JW Pharmaceutical
Responsible party
Sponsor
First posted
Oct 30, 2024
Start date
Mar 24, 2025
Primary completion
May 2, 2025
Completion
Sep 4, 2025
Last update
Apr 20, 2026

Study contacts

Kyung-sang Yu, MD
principal investigator · Seoul National University Hospital

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.

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