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CompletedNCT06658392CFDDCNUpdated Oct 26, 2024

Domain-general and Domain-specific Contributions to the Development of Numerical Cognition

An interventional study of cognitive tasks in No Condition, sponsored by Centre Hospitalier St Anne. Completed at 1 site in France. Open to participants aged 5 Years to 7 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-10-26.

Sponsored by Centre Hospitalier St Anne · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Registered 3 years 6 months after the study started (first participant enrolled Mar 2021, registered Oct 2024).
Phase
Not applicable
Study type
Interventional
Enrollment
58
Allocation
Not applicable
Ages
5 Years to 7 Years
Sex
All
01

Study summary

Exploring the non-symbolic and symbolic arithmetic competencies in two groups of children (5-, and 7-year-olds). Additionally, we explored the relationship with domain-general factors such as inhibition and attention. Recorded fMRI.

Read the detailed description

Using T2*-weighted eip imaging, we measured BOLD response in two cohorts of healthy children while they were doing different cognitive tasks in the scanner. These tasks included solving non-symbolic (i.e. sets of elements) and symbolic (i.e. Arabic digits) addition and subtraction problems, a color control task, an attentional task measuring different facets of spatial attention, and a task measuring inhibition. We also recorded a high-resolution anatomical scan of the brain.

02

Conditions studied

  • No Condition

Keywords

  • cognitive neuroscience
  • numerical cognition
03

In context

Lead sponsor

Centre Hospitalier St Anne is the lead sponsor of 99 studies on the registry; 53 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
5 Years to 7 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • school enrollment
  • French as mother tongue
  • right-handed
  • normal medical, neurological and neuroradiological examinations - parents affiliated to a social security scheme

Exclusion criteria

Exclusion Criteria:

  • not within age range
  • monocygotic twins
    • contraindications to an MRI examination (neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic ocular or cerebral foreign bodies close to nerve structures, metal prostheses, patient agitation: uncooperative or agitated patients, claustrophobic subjects, ventriculoperitoneal neurosurgical shunt valves, dental apparatus, etc.).
  • sudden onset of cognitive problems that could indicate a stroke; a history of head trauma with loss of consciousness lasting more than 1 hour, or encephalitis; - a chronic neurological, psychiatric, endocrine, hepatic or infectious condition
  • a history of major illness (diabetes, chronic lung disease, severe cardiac, metabolic, hematological, endocrinological or immunological disorders, cancer); - medication likely to interfere with brain imaging measurements
  • color blindness or uncorrected visual disorders
  • inability to take part in the study for geographical or psychiatric reasons
  • presence of pervasive developmental and/or acquisition disorders identified by parents or legal guardians and/or teachers
  • cerebral palsy
  • impaired fine motor skills
  • parents or legal guardians not affiliated to a social security scheme
  • unaccompanied by parent(s) or legal guardian(s) during visits.
  • tattoo not compatible with MRI
  • children and parents under legal protection
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
58 participants (actual)

Study arms

  • Experimental
    arithmetic

    exploring neurocognitive mechanisms underlying development of arithmetic competencies in healthy children.

    Other: cognitive tasks

Interventions

  • Othercognitive tasks

    no intervention in a medical sense, only observing changes of BOLD signal during different experimental conditions in cognitive tasks (arithmetic, attention, inhibition)

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What researchers measure

Primary outcomes

  1. BOLD response

    changes of BOLD response under different experimental conditions (non-symbolic arithmetic; symbolic arithmetic; inhibition; attention)

    Time frame: BOLD response recorded during fMRI session

  2. BOLD response

    changes of BOLD response in experimental conditions

    Time frame: during fMRI session

07

Study locations

1 site
  • Centre Hospitalier Sainte-Anne
    Paris, 75014, France
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 26, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06658392
Lead sponsor
Centre Hospitalier St Anne
Responsible party
Sponsor
First posted
Oct 26, 2024
Start date
Mar 30, 2021
Primary completion
Sep 27, 2024
Completion
Sep 27, 2024
Last update
Oct 26, 2024

Study contacts

Catherine OPPENHEIM, Pr
principal investigator · Promotor

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Sep 2024. You cannot join it, but the record below documents what was studied.

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