An observational study in Obesity, fMRI and Clinical Classification, sponsored by The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School. Enrolling by invitation at 1 site in China. Open to participants aged 20 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-10-18.
Sponsored by The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Observational
This is an observational study to explore the etiology and clinical classification in patients with obesity and to achieve personalized treatment.
In this project, individuals with obesity and control individuals were recruited and followed up every year. Clinical neuropsychological scores, olfactory function tests, and functional magnetic resonance imaging (fmri) were performed to describe the brain function characteristics under different odor stimulation in fasting and after eating, and to explore the pathogenesis and clinical classification of obese patients. The correlation analysis between imaging analysis values and clinical laboratory data, neuropsychological scores and olfactory behavior scores was performed to explore indicators related to cognitive decline and provide new insights into the etiology and classification of obese patients. Combined with clinical evaluation and imaging examination, the changes of cognitive behavior and brain structure and function in obese patients were followed up.
6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.
This study's planned enrollment of 100 is below the median of 135 across 1,283 observational studies indexed under Obesity.
Browse Obesity studies →The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School is the lead sponsor of 242 studies on the registry; 144 are open to participants now.
Counted across the registry records on this site, refreshed daily.
This study is a dynamic prospective cohort study.
Exclusion Criteria:
Naturalistic observation
Brain imaging features in patients with obesity by fMRI
total brain volume, grey matter volume, white matter volume,cerebrospinal fluid volume, and nuclear bulk volume by MRI-derived normalized measures. All patients underwent odor-induced task fMRI on a 3.0T MR scanner with 222 volumes for task fMRI and 230 volumes for resting-state fMRI.
Time frame: From 2024 to 2028
Biomarkers of patients with obesity by blood sample
Diagnostic biomarkers, predictive biomarkers, and prognostic biomarker in patients with obesity by blood sample
Time frame: From 2024 to 2028
Clinical classification of patients with obesity
Based on the exploration of the unique brain imaging and biomarkers in patients with obesity, the clinical classification of obese patients was carried out.
Time frame: From 2024 to 2028
Prevention and intervention strategies for obesity based on clinical classification
According to the clinical classification of obesity investigated in our previous study, personalized prevention and treatment strategies are designed to effectively slow down or reverse the obesity disease.
Time frame: From 2024 to 2028
Plan to share: No
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The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School