ClinicalTrials.gg
RecruitingNCT06624982Updated Nov 17, 2025

Determinants of Bone Dimensional Changes After Extraction and Alveolar Ridge Preservation

An observational study in Alveolar Bone Grafting, Bone Healing and Tooth Extraction Site Healing, sponsored by Marquette University. Recruiting at 1 site in United States. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-11-17.

Sponsored by Marquette University · Observational

From the registry’s dates

  • Started Oct 2025; still recruiting 1 year 1 month later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
160
Ages
18 Years to 75 Years
Sex
All
01

Study summary

The main purpose of the study is to measure and localize immediate post extraction changes i.e. socket expansion versus no width change along the socket wall and identify whether the immediate post-extraction ridge width condition (expansion or no change) is a determinant of buccolingual ridge width and height changes 4 months following extraction and ridge preservation.

Read the detailed description

The null hypothesis for this study is that there is no difference in bone ridge width and height changes 4 months following extraction and alveolar ridge preservation at sites that undergo immediate post-extraction socket expansion or no immediate post-extraction ridge width change. Patients of the Graduate Periodontics Clinic at Marquette University School of Dentistry scheduled for extraction, bone graft and resorbable membrane will be recruited for this study.

After providing informed consent and prior to local anesthesia and extraction, the following parameters will be recorded: age, gender, race, medical history, medications, tooth site, reason for extraction and tooth mobility. Gingival width will be recorded prior to local anesthesia and extraction, and at 4 months. Gingival thickness will be recorded after local anesthesia and prior to extraction, and at 4 months. Buccolingual ridge width and ridge height will be recorded immediately before, immediately after extraction, and at 4 months. Immediately after extraction, the following measurements will be recorded: buccal bone thickness, number of roots, root length and width, instruments used for extraction, need for flap elevation, duration of extraction, anesthetic amount, type and approach, and operator experience.

02

Conditions studied

  • Alveolar Bone Grafting
  • Bone Healing
  • Tooth Extraction Site Healing
  • Wound Healing
03

In context

Lead sponsor

Marquette University is the lead sponsor of 38 studies on the registry; 10 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Patients scheduled for tooth extraction and alveolar ridge preservation (bone graft and membrane) in the Graduate Periodontics Clinic at Marquette University School of Dentistry.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adult patients (18-75 years)
  • Good general health (controlled conditions)
  • Controlled periodontal disease
  • Scheduled for single tooth extraction with bone graft placement and resorbable membrane
  • Tooth to be extracted must have adjacent teeth
  • Socket wall integrity

Exclusion criteria

Exclusion Criteria:

  • Smoking
  • Pregnancy
  • Active periodontal disease
  • Systemic conditions that affect healing
  • Lack of socket wall integrity (bone loss ≥50 %) prior to extraction, teeth with severe infection requiring pre-extraction antibiotic treatment to control infection), and for tooth extraction.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
160 participants (estimated)
Patient registry
No

Groups and cohorts

  • Non-molar sites with immediate post-extraction ridge expansion

    Non-molar sites with an increase of buccolingual bone width immediately after tooth extraction compared to pre-extraction.

    Other: observational study

  • Non-molar sites with no immediate post-extraction ridge width change

    Non-molar sites without a change in buccolingual bone width immediately after tooth extraction compared to pre-extraction.

    Other: observational study

  • Molar sites with immediate post-extraction ridge expansion

    Molar sites with an increase of buccolingual bone width immediately after tooth extraction compared to pre-extraction.

    Other: observational study

  • Molar sites with no immediate post-extraction ridge width change

    Molar sites without a change in buccolingual bone width immediately after tooth extraction compared to pre-extraction.

    Other: observational study

Interventions

  • Otherobservational study

    Observational study; alveolar ridge preservation

06

What researchers measure

Primary outcomes

  1. Buccolingual ridge width

    Buccolingual ridge width will be measured through a stent via ridge mapping calipers. The measurement locations will be at 1mm, 3mm and 5mm from the midbuccal crest. The same measurements will be recorded at all selected time points.

    Time frame: (1) After local anesthesia and before extraction, (2) immediately after extraction and (3) 4 months after extraction and alveolar ridge preservation

  2. Ridge height

    Ridge height will be measured through a stent via a periodontal probe as the distance between bone and predetermined landmarks on the stent. The measurement locations will be mesial buccal, midbuccal, distal buccal, mesial lingual, midlingual and distal lingual. The same measurements will be recorded at all selected time points.

    Time frame: (1) After local anesthesia and before extraction, (2) immediately after extraction and (3) 4 months after extraction and alveolar ridge preservation

07

Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 17, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06624982
Lead sponsor
Marquette University
Responsible party
Vrisiis Kofina (Director, Advanced Education in Periodontics Program, Assistant Professor of Periodontics, Marquette University) — Principal investigator
First posted
Oct 3, 2024
Start date
Oct 8, 2025
Primary completion
Oct 1, 2027 (estimated)
Completion
Oct 1, 2027 (estimated)
Last update
Nov 17, 2025

Study contacts

Vrisiis Kofina, DDS, MS
Contact
vrisiis.kofina@marquette.edu
4142886521
Samah Rady, DDS
Contact
samahsy.rady@marquette.edu
9497962173
Vrisiis Kofina, DDS, MS
principal investigator · Marquette University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion