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CompletedNCT06617390RECAPUpdated Aug 3, 2025

A Study of Real-world Treatment Patterns and Outcomes in Chinese Advanced NSCLC Patients Who Previously Received at Least 2 Line Treatments

An observational study in Non-small Cell Lung Cancer (NSCLC), sponsored by Daiichi Sankyo. Completed at 6 sites in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-08-03.

Sponsored by Daiichi Sankyo · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
1,041
Ages
18 Years and older
Sex
All
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Study summary

This study will retrospectively collect data of patients with advanced non-small cell lung cancer who have received at least 2 line treatment to investigate treatment patterns, relevant outcomes, and biomarkers detection patterns in Chinese patients with Actionable Genomic Alterations (AGA) or non-AGA.

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Conditions studied

  • Non-small Cell Lung Cancer (NSCLC)

Keywords

  • NSCLC
  • Lung Cancer
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In context

Carcinoma, Non-Small-Cell Lung

6,488 studies on the registry are indexed under Carcinoma, Non-Small-Cell Lung; 1,632 are open to participants now.

This study's enrollment of 1,041 is above the median of 161 across 949 observational studies indexed under Carcinoma, Non-Small-Cell Lung.

Browse Carcinoma, Non-Small-Cell Lung studies →

Lead sponsor

Daiichi Sankyo is the lead sponsor of 316 studies on the registry; 35 are open to participants now.

Of its 51 completed or terminated interventional studies of FDA-regulated products, 38 (75%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Participants with advanced NSCLC who have received at least 2L treatment between September 1, 2019, and December 31, 2022.

Inclusion criteria

  1. Participants aged ≥18 years when diagnosed with advanced NSCLC.
  2. Histologically or cytologically confirmed stage IV NSCLC.
  3. For non-AGA participants , second- or third-line systemic treatment occurred between September 1, 2019 and December 31, 2022, and participants received corresponding immunotherapy in the first or second line.
  4. For AGA participants , second- or third-line systemic treatment occurred between September 1, 2019 and December 31, 2022. Among them, participants with documented positive result for EGFR, ALK, or ROS1 testing received corresponding targeted therapy in the first or second line.

Exclusion criteria

Exclusion Criteria:

This study excludes participants who met any of the following criteria.

  1. Having records of participation or past participation in clinical trial for lung cancer within the data collection period of the study.
  2. Participants with a concomitant cancer at the time of diagnosis of NSCLC (except for non-metastatic non-melanoma skin cancers, in situ or benign neoplasms). Occurrence of cancer within 5 years after NSCLC diagnosis will be considered as secondary cancer.
  3. Histology of the tumor is small cell lung cancer, neuroendocrine in origin, or a mixed histologic type with small cell and non-small cell lung cancers.
  4. Participants with significantly missing medical record data or patients deemed inappropriate for inclusion by investigators.
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
1,041 participants (actual)
Patient registry
No

Groups and cohorts

  • AGA Cohort

    NSCLC participants with AGA that received second-line or above therapies treatment.

    Other: No drug

  • Non-AGA Cohort

    NSCLC participants with non-AGA that received second-line or above therapies treatment.

    Other: No drug

Interventions

  • OtherNo drug

    This is a non-interventional study and no study drug will be provided.

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What researchers measure

Primary outcomes

  1. Percentage of real-world treatment regimens for second- or third-line therapy in patients with advanced NSCLC

    Time frame: 40 months

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Study locations

6 sites
  • Beijing Cancer Hospital
    Beijing, China
  • The First Affiliated Hospital of Fujian Medical University
    Fuzhou, China
  • Sun Yat-sen University Cancer Center
    Guangzhou, China
  • Affiliated Cancer Hospital of Shandong First Medical University
    Jinan, China
  • Liaoning Cancer Hospital & Institute
    Shenyang, China
  • The First Affiliated Hospital of Soochow University
    Suzhou, China
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 3, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06617390
Lead sponsor
Daiichi Sankyo
Responsible party
Sponsor
First posted
Sep 27, 2024
Start date
Aug 15, 2024
Primary completion
Jan 26, 2025
Completion
Jul 30, 2025
Last update
Aug 3, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.

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