An interventional study of Cycling Training in Spinocerebellar Ataxias, sponsored by Chang Gung University. Recruiting at 1 site in Taiwan. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-10-08.
Sponsored by Chang Gung University · Not applicable, Interventional, and Treatment
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Among 10 studies in Spinocerebellar Ataxias with a site in Taiwan — 4 open to participants now, 5 under way, none of them phase 3. Spinocerebellar Ataxias · Taiwan.
Among the 10 studies in Spinocerebellar Ataxias with a site in Taiwan, this one is the 4th largest by planned enrollment, is one of 3 that started in 2024, is one of 7 with no phase, and was the 8th registered.
95 studies on the registry are indexed under Spinocerebellar Ataxias; 25 are open to participants now.
Browse Spinocerebellar Ataxias studies →4 of the 10 studies in Spinocerebellar Ataxias with a site in Taiwan are open now. Recruiting first, the newest first:
ALPS Biotech CO. LTD · Sites in Taiwan
Ages 30–70
Changhua Christian Hospital · Sites in Taiwan
Ages 18–65
Chang Gung University · Sites in Taiwan
Ages 20+ · Healthy volunteers
A study can be open while its sites in Taiwan have not opened yet or have stopped. Only those recruiting at a site in Taiwan →
Of the 16 Spinocerebellar Ataxias studies recruiting now, 8 (50%) set no upper age limit and 3 (19%) stop at 75 or younger; 4 take children under 18; 5 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
10 studies; the count open now beside each. This study's row is marked.
First in 2002; this study’s year is marked. 3 started in 2024.
This study's planned enrollment of 40 is above the median of 29 across 61 interventional studies indexed under Spinocerebellar Ataxias.
Median enrollment 40 across the 10 interventional studies. Of the 5 that completed or were terminated, 0 (0%) have results posted.
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3 of 10 have an industry lead sponsor. The 5 most frequent:
Chang Gung University is the lead sponsor of 66 studies on the registry; 13 are open to participants now.
Chang Gung University has 5 studies filed under Spinocerebellar Ataxias — fewer than ten, so there is no comparison to draw.
2 of the studies in Spinocerebellar Ataxias with a site in Taiwan that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06672445Arrowhead PharmaceuticalsStudy of ARO-ATXN2 Injection in Adults With Spinocerebellar Ataxia Type 2 | 2026-12 |
| NCT06633003ALPS Biotech CO. LTDEffects of Oral Administration of Antrodia Cinnamomea Products for Clinical Symptoms in Spinocerebellar Ataxia Patients | 2027-08-31 |
Add all 2 to your calendar (.ics) → With an account.
Among the 10 studies in Spinocerebellar Ataxias with a site in Taiwan, from their registry updates:
Nothing recorded among them since 2026-09-25.
This tab as a report to print or save as PDF → With an account.
Effective walking and balance require not only lower limb muscle strength but also coordinated movement. For individuals with Spinocerebellar Ataxia (SCA), rehabilitation strategies targeting coordination are essential to improving mobility and reducing the burden on caregivers. However, evidence-based rehabilitation approaches for ataxia remain limited.
Recent studies suggest that improvements in motor learning are often accompanied by changes in cortical excitability. Abnormal cortical excitability in SCA patients may hinder rehabilitation efforts, yet priming strategies-such as exercise or specific stimuli-have been shown to enhance motor learning by modulating cortical excitability. Cycling exercise, in particular, has demonstrated the potential to improve coordination and influence cortical plasticity in individuals with SCA, making it a promising priming strategy for coordination training.
This clinical trial aims to:
This study seeks to provide insights into optimized rehabilitation interventions that could enhance the quality of life and independence for people with SCA.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Long-term training
Procedure: Cycling Training
Control group
Cycling combined with priming strategies to enhance motor learning tasks. Each session will last for 15 minutes, conducted three times per week, over a period of two weeks.
Overall Response Time
The sum of reaction time and movement time, providing a complete measure of the time taken from the stimulus presentation to the completion of the response. Unit: Second(s)
Time frame: Baseline, 2 weeks and 4 weeks
Overall Error Rate
The total proportion of incorrect responses across a testing session or series of tasks.
Time frame: Baseline, 2 weeks and 4 weeks
Motor Evoked Potentials (MEPs)
MEPs are the electrical responses recorded from muscles following stimulation of the motor cortex. They reflect the efficiency of neural transmission from the cortex to the muscle. Unit: millivolts (mV).
Time frame: Baseline, 2 weeks and 4 weeks
Intracortical Facilitation (ICF)
ICF is measured by applying a pair of TMS pulses with a short interval (e.g., 8-15 ms) where the first (subthreshold) pulse is followed by a second (suprathreshold) pulse, leading to an increased amplitude of the MEP.
Time frame: Baseline, 2 weeks and 4 weeks
Intracortical Inhibition (ICI)
ICI is measured similarly to ICF but with a shorter inter-stimulus interval (e.g., 1-5 ms), resulting in a suppressed MEP amplitude. This suppression reflects inhibitory processes within the cortex.
Time frame: Baseline, 2 weeks, and 4 weeks
Total Scale for the Assessment and Rating of Ataxia (SARA) Score
To objectively assess ataxia severity across various domains of motor function including gait, stance, sitting, speech disturbance, finger chase, nose-finger test, fast alternating hand movements, and heel-shin slide. Each item is scored individually with a scale that typically ranges from 0 (no ataxia) to a maximum score that depends on the severity and the aspect of ataxia being assessed. The total score ranges from 0 (no ataxia) to 40 (most severe ataxia).
Time frame: Baseline, 2 weeks, and 4 weeks
Total Berg Balance Scale (BBS) Score
To measure an individual's balance abilities through various tasks that mimic daily activities, assessing the risk of falls and overall balance proficiency. The BBS consists of 14 items that evaluate a range of functions including sitting to standing, standing unsupported, transferring, turning to look behind, picking up an object from the floor, and standing on one leg. Each task is rated on a scale from 0 (unable) to 4 (independent), with the total score ranging from 0 to 56. A higher total score indicates better balance and lower fall risk. Scores below 45 are generally indicative of increased fall risk.
Time frame: Baseline, 2 weeks, and 4 weeks
Total Time to Complete the Time Up and Go test (TUG test)
The time, in seconds, it takes for a participant to complete the TUG test from the initial sitting position to returning to the seated position. An older adult who takes ≥12 seconds to complete the TUG is at risk for falling.
Time frame: Baseline, 2 weeks, and 4 weeks
Walking Speed
The time taken by participants to walk a standardized distance, typically expressed in centimeters per second (cm/s).
Time frame: Baseline, 2 weeks, and 4 weeks
Step Length
The linear distance between the two ankles, typically expressed in centimeter(cm).
Time frame: Baseline, 2 weeks, and 4 weeks
Step Time
The duration taken for one complete step, measuring from foot-off of one foot to the next foot-off of the same foot, usually expressed in seconds.
Time frame: Baseline, 2 weeks, and 4 weeks
Fatigue Level Measurement Using Multidimensional Fatigue Inventory (MFI)
The MFI is a 20-item self-report questionnaire used to measure five dimensions of fatigue: general fatigue, physical fatigue, mental fatigue, reduced activity, and reduced motivation. Each dimension is scored separately, with higher scores indicating greater fatigue
Time frame: Baseline, 2 weeks, and 4 weeks
Sleep Quality Measurement Using Pittsburgh Sleep Quality Index (PSQI)
The PSQI is a 19-item self-report questionnaire that assesses sleep quality over a 1-month period. It generates a global score ranging from 0 to 21, with higher scores indicating poorer sleep quality. The PSQI includes seven components: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleep medication, and daytime dysfunction.
Time frame: Baseline, 2 weeks, and 4 weeks
Gait Speed Measurement Using 10-Meter Walk Test (10MWT)
The 10MWT is a performance-based measure used to assess walking speed over a short distance. Participants will be instructed to walk 10 meters at their comfortable and/or fastest walking speed. The time taken to walk the central 6 meters is recorded to eliminate acceleration and deceleration effects, and gait speed is calculated as meters per second (m/s).
Time frame: Baseline, 2 weeks, and 4 weeks
Double Support Time
The portion of the gait cycle where both feet are in contact with the ground, indicating the transition phase between steps, expressed as a percentage of the gait cycle or in seconds.
Time frame: Baseline, 2 weeks, and 4 weeks
Single Support Time
The duration within the gait cycle when only one foot is in contact with the ground, typically measured in seconds or as a percentage of the total gait cycle.
Time frame: Baseline, 2 weeks, and 4 weeks
Swing Time
The portion of the gait cycle where the foot is not in contact with the ground, moving forward to the next step. It is usually expressed as a percentage of the total gait cycle or in seconds.
Time frame: Baseline, 2 weeks, and 4 weeks
Stance Time
The portion of the gait cycle when the foot is in contact with the ground, supporting body weight. It's typically expressed as a percentage of the total gait cycle or in seconds
Time frame: Baseline, 2 weeks, and 4 weeks
Cadence
The number of steps an individual takes per minute, providing an overview of gait speed and rhythm, , expressed as steps per minute.
Time frame: Baseline, 2 weeks, and 4 weeks
Started Oct 2024 (actual). Primary completion is estimated for Aug 2026, 22 months after the start.
Of 28 interventional studies with no phase under Spinocerebellar Ataxias, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 30. This study's planned 22 months is close to that.
How these figures are worked out, and which studies are left out of them.
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Chang Gung University