An interventional study of Eccentric cycling training and Concentric cycling training in Eccentric Exercise Training, sponsored by Chang Gung Memorial Hospital. Completed at 1 site in Taiwan. Open to male participants aged 20 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-08-29.
Sponsored by Chang Gung Memorial Hospital · Not applicable, Interventional, and Treatment
Eccentric cycling exercise (ECE) features lower metabolic demand and higher improvement of muscle strength compared to traditional concentric cycling exercise (CCE). Mitochondria can regulate energy metabolism and adaptive immune quality in T lymphocytes. However, the effects of ECE on mitochondrial functions in T-lymphocytes have not yet been established.
Method: A total of 33 healthy sedentary males were randomized and divided into ECE (n=11), CCE (n=11), and control groups (n=11). These subjects progressively performed CCE or ECE from 60% to 80% maximal workload on a bicycle ergometer for 40 min/day, 5 days/week for 6 weeks. A graded exercise testing and an isokinetic strength test were conducted to evaluate cardiopulmonary fitness and muscle strength, respectively. Phenotypes and mitochondrial respiratory capacity in T lymphocyte were analyzed using flow cytometry and high-resolution respirometer, respectively.
Eccentric exercise training (EET) increases physical performance while having lower metabolic demand than concentric exercise training (CET).
Mitochondria of lymphocytes are essential for cell proliferation, death, and differentiation, and play a critical role in establishing lymphocyte phenotypes and their functions.
Whether EET influences lymphocyte bioenergetic efficiency remains unclear. The study was to investigate the effects of ECE and CCE regimens on adaptive immune functions and mitochondrial bioenergetics of T lymphocytes in sedentary males.
Chang Gung Memorial Hospital is the lead sponsor of 1,064 studies on the registry; 235 are open to participants now.
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Exclusion Criteria:
Moderate to high intensity cycling training in eccentric type
Behavioral: Eccentric cycling training
Moderate to high intensity cycling training in concentric type (intensity matched the eccentric training)
Behavioral: Concentric cycling training
without receiving any exercise training
Performed exercise training 5 days a week for 6 weeks on an eccentric ergometer. Each training session: 5 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase. Intensity: Firstly, set at 60% Wmax, and progressively increased 5% per week
Performed exercise training 5 days a week for 6 weeks on an eccentric ergometer. Each training session: 5 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase. Intensity: Firstly, set at 60% Wmax, and progressively increased 5% per week
Mitochondrial function of lymphocyte
Evaluate bioenergetic health index (BHI) of mitochondria in lymphocyte by using a high resolution respirometer.
Time frame: 12 weeks
Cardiopulmonary fitness
The graded exercise test (GXT) on a bicycle ergometer was performed. The GXT comprised 2 min of unloaded pedaling followed by a continuous increase in the work rate of 30 watt per 3-minute until exhaustion (i.e., progressive exercise to maximal O2 consumption)
Time frame: 12 weeks
Plan to share: No
This study is completed, as verified in Aug 2024. You cannot join it, but the record below documents what was studied.
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Chang Gung Memorial Hospital