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RecruitingNCT06575439OLIVEUpdated Dec 12, 2024

An Observational Study of Predictors and Outcomes of Lung Cancer in Never-smokers in the UK

An observational study in Lung Cancer, sponsored by University College London Hospitals. Recruiting at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-12-12.

Sponsored by University College London Hospitals · Observational

From the registry’s dates

  • Started Sep 2024; still recruiting 2 years 1 month later.
Study type
Observational
Model
Cohort
Time perspective
Other
Enrollment
225
Ages
18 Years and older
Sex
All
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Study summary

The goal of this observational study is to improve the early detection of lung cancer in adults who have smoked less than 100 tobacco cigarettes ("never-smokers") in the United Kingdom. The main questions it aims to answer are:

  • To describe characteristics such as demographics, co-morbidities and environmental exposures
  • To describe participant pathways including presentation mode and symptoms to understand if earlier diagnosis would be possible
  • To describe participant outcomes such as cancer stage, treatment and mortality
  • To quantitatively or qualitatively measure modifiable and non-modifiable factors that may be associated with LCINS including environmental measures, blood tests and genomic data.

Participants will currently have no change to their usual care.

02

Conditions studied

  • Lung Cancer

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03

In context

Lung Neoplasms

5,422 studies on the registry are indexed under Lung Neoplasms; 1,346 are open to participants now.

This study's planned enrollment of 225 is above the median of 200 across 1,434 observational studies indexed under Lung Neoplasms.

Browse Lung Neoplasms studies →

Lead sponsor

University College London Hospitals is the lead sponsor of 62 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

This study will aim to recruit participants who have been diagnosed or treated with primary lung cancer at any participating study site.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • All adult participants from age of 18 who are diagnosed or treated with primary lung cancer through radiology or histology at any participating study site

Exclusion criteria

Exclusion Criteria:

  • Participants who have ever smoked cigarettes or tobacco will be excluded; this is defined as:

    • More than 100 cigarettes or 75g tobacco in their lifetime
    • Those who have received a prescription for nicotine replacement therapy
  • For prospective participants, those who cannot consent will be excluded
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Study design

Observational model
Cohort
Time perspective
Other
Enrollment
225 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Demographics, comorbidities and environmental exposures of participants

    From review of electronic health records

    Time frame: Comorbidities and environmental exposures at diagnosis (approximately up to 156 weeks prior to diagnosis)

  2. Participant pathways including presentation mode and symptoms

    From review of electronic health records

    Time frame: Presentation mode and symptoms at time of diagnosis (approximately up to 52 weeks prior to diagnosis)

Secondary outcomes

  1. Participant outcomes such as cancer stage, treatment, mortality

    From review of electronic health records

    Time frame: Cancer stage at time of diagnosis, treatment and mortality through study completion (likely 5 years)

  2. Measurement of modifiable and non-modifiable factors associated with LCINS

    To be determined

    Time frame: Through study completion (likely 5 years)

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Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: No — No individual participant data will be made available to non-study researchers (as per current ethics approval).

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 12, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06575439
Lead sponsor
University College London Hospitals
Responsible party
Neal Navani (Professor of Respiratory Medicine, University College, London) — Principal investigator
First posted
Aug 28, 2024
Start date
Sep 17, 2024
Primary completion
Sep 2029 (estimated)
Completion
Sep 2029 (estimated)
Last update
Dec 12, 2024

Study contacts

Neal Navani, PhD
Contact
n.navani@ucl.ac.uk
020 7679 2000
Sindhu Naidu, MBBS
Contact
s.naidu@ucl.ac.uk
020 7679 2000

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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