An interventional study of 5A's/5R's advice and Brief leaflet on health warning and smoking cessation in Smoking Cessation and Mobile Health, sponsored by Beijing Normal University. Active, not recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-09.
Sponsored by Beijing Normal University · Not applicable, Interventional, and Health services research
This study aims to explore the feasibility and effectiveness of AI-powered chatbot support in community smokers.
Smoking cessation remains one of the most significant public health challenges worldwide, with tobacco use being a leading cause of preventable death and disease. Despite extensive efforts, the success rates of smoking cessation programs remain low, necessitating innovative approaches to support individuals in their journey to quit smoking. Recently, artificial intelligence (AI) has opened new possibilities in healthcare, including the development of AI-powered chatbots that assist individuals in behavior change, such as quitting smoking.
This randomized controlled trial aims to investigate the effectiveness of AI-powered chatbot that simulates human counselors in promoting smoking cessation among community smokers. The AI-powered chatbot, equipped with personalized interactions and real-time support, offers scalable and cost-effective assistance, potentially making it an accessible alternative to human counseling. However, human counselors provide empathy, tailored advice, and a nuanced understanding of human behavior that AI may not fully replicate. This study will explore which approach the feasibility and effectiveness of AI-powered chatbot support in community smokers.
1,581 studies on the registry are indexed under Smoking Cessation; 198 are open to participants now.
This study's planned enrollment of 420 is above the median of 164 across 1,423 interventional studies indexed under Smoking Cessation.
Browse Smoking Cessation studies →Beijing Normal University is the lead sponsor of 31 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
AI-powered chatbot support+ 5A's/5R's advice + health warning leaflet+ Self-help booklet
Behavioral: 5A's/5R's advice · Other: Brief leaflet on health warning and smoking cessation · Other: Self-help smoking cessation booklet · Behavioral: AI-powered chatbot support
Counselor individual support+ 5A's/5R's advice + health warning leaflet+ Self-help booklet
Behavioral: 5A's/5R's advice · Other: Brief leaflet on health warning and smoking cessation · Other: Self-help smoking cessation booklet · Behavioral: Counselor individual support
5A's/5R's advice + health warning leaflet+ Self-help booklet
Behavioral: 5A's/5R's advice · Other: Brief leaflet on health warning and smoking cessation · Other: Self-help smoking cessation booklet
5A's (Ask, Advise, Assess, Assist, Arrange) for smokers who are ready to quit, and 5R's (relevance, risks, rewards, roadblocks, and repetition) for smokers who are not ready to quit.
The contents of the leaflet include the absolute risk of smoking, diseases caused by active and second-hand smoking, horrible pictorial warnings of the health consequences of active and second-hand smoking, and the benefits of quitting.
The contents include information about the benefits of quitting, methods to quit, how to handle withdrawal symptoms, misperceptions of quitting, etc.
Participants will receive three months of AI-powered chatbot, equipped with personalized interactions and real-time support, via WeChat.
Participants will receive three months of counselor-led individual support via WeChat. The regular messages and instant messaging on psychosocial support aim to provide cessation advice, increase self-efficacy and confidence, and social support and behavioral capacity of quitting.
Biochemical validated quit rate at 6 months follow-up
The primary outcomes are biochemically validated quit rate (exhaled carbon monoxide \< 4 ppm or salivary cotinine \< 30 ng/ml)
Time frame: 6 months follow-up
Biochemical validated quit rate at 3 months follow-up
biochemically validated quit rate (exhaled carbon monoxide \< 4 ppm or salivary cotinine \< 30 ng/ml)
Time frame: 3 months follow-up
Self-reported 7-day point prevalence quit rate
Self-reported 7-day point prevalence quit rate in the two groups
Time frame: 3 and 6 months follow-up
Smoking reduction rate
Rate of smoking reduction by at least half of baseline amount in the two groups
Time frame: 3 and 6 months follow-up
Eligibility rate
the percentage of eligible smokers out of the total number of smokers screened
Time frame: baseline
Consent rate
the percentage of eligible smokers who agree to participate out of the total number of eligible smokers
Time frame: baseline
Percentage of Participant Engagement with E-Messages and Counselor Chats
This outcome measures the percentage of participants who engage with the intervention by reading e-messages and responding to counselor chat messages at least once during the 3-month follow-up period.
Time frame: 3 months follow-up
This study is active, not recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Beijing Normal University