An interventional study of Standard HD-tDCS intervention and Multifocal network targeted HD-tDCS intervention in Healthy, sponsored by University of Michigan. Recruiting at 1 site in United States. Open to participants aged 65 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-17.
Sponsored by University of Michigan · Not applicable, Interventional, and Basic science
The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain processes to improve behavior. Participants in this study will be randomized to either HD-tDCS with standard intervention or personalized dose-controlled multifocal network-targeted HD-tDCS.
The hypothesis is that dexterous hand function will improve after a standard HD-tDCS dose and increase even more after personalized dose-controlled multifocal network-targeted HD-tDCS.
This project is the first of two projects. The second project will be registered as a separate project in the future and enroll participants from this project.
University of Michigan is the lead sponsor of 1,476 studies on the registry; 197 are open to participants now.
Of its 162 completed or terminated interventional studies of FDA-regulated products, 128 (79%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants will have three daily sessions.
Device: Standard HD-tDCS intervention · Device: Functional Magnetic Resonance Imaging (fMRI)
Participants will have three daily sessions.
Device: Multifocal network targeted HD-tDCS intervention · Device: Functional Magnetic Resonance Imaging (fMRI)
Participants will have three sessions along with behavioral assessments.
Participants will have three sessions along with behavioral assessments.
Participants will have an MRI before or after having HD-tDCS intervention.
Percent change in precision force-tracking task
Squared distance (error) from the cursor to the target in precision force-tracking task, estimated as the root mean squared error (RMSE).
Time frame: Baseline and 24 hours after the third sessions are completed
Percentage change in the time to complete the nine-hole peg test (9-HPT)
9-hole peg test is a manual dexterity measure, estimated as the time required to complete the task (seconds).
Time frame: Baseline and 24 hours after the third sessions are completed
Percentage change in the mean choice reaction time
Mean reaction time for subjects responding in the 2-choice reaction time control task, for correct responses
Time frame: Baseline and 24 hours after the third sessions are completed
Plan to share: No
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University of Michigan