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RecruitingNCT06548711Updated Sep 8, 2025

Effect of Transcutaneous Acupoint Electrical Stimulation (TAES) on Postoperative Cough in Lung Cancer

An interventional study of Transcutaneous Acupoint Electrical Stimulation (TAES) in Postoperative Cough and Lung Cancer, sponsored by Kong Fanming. Recruiting at 1 site in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-09-08.

Sponsored by Kong Fanming · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Apr 2026, 5 months ago, but the record still lists the study as recruiting.
  • Registered 3 months after the study started (first participant enrolled Apr 2024, registered Jul 2024).
  • Started Apr 2024; still recruiting 2 years 5 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
84
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

Observation and exploration of the improvement in cough symptoms in postoperative lung cancer patients with Transcutaneous Acupoint Electrical Stimulation (TAES), the change in Cough Symptom Score (CSS) compared to baseline, the change in Visual Analog Scale (VAS) score for cough symptoms compared to baseline, the change in total score of Leicester Cough Questionnaire-Mandarin Chinese version (LCQ-MC) compared to baseline, and overall evaluation of treatment effectiveness by patients. A total of 84 postoperative lung cancer patients with cough were strictly selected according to the inclusion/exclusion criteria and treated and followed up according to the research plan requirements. Clinical observation forms were completed and clinical data were recorded in the database. Statistical analysis was performed on relevant clinical observation indicators to report research results and write related papers.

Read the detailed description

To obtain sufficient evidence from evidence-based medicine, prospective, random, blind, and controlled clinical trials are adopted to evaluate the effectiveness and safety of TEAS in treating postoperative cough in lung cancer patients. This study aims to provide a potential non-pharmacological treatment option for postoperative cough patients with lung cancer, improve the quality of life of postoperative lung cancer patients, identify the population that is more likely to benefit from TEAS treatment and provide a solid scientific basis and guidance for personalized acupuncture treatment for postoperative cough in lung cancer patients.

02

Conditions studied

  • Postoperative Cough
  • Lung Cancer

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03

In context

Lung Neoplasms

7,243 studies on the registry are indexed under Lung Neoplasms; 1,557 are open to participants now.

This study's planned enrollment of 84 is above the median of 60 across 5,295 interventional studies indexed under Lung Neoplasms.

Browse Lung Neoplasms studies →

Lead sponsor

Kong Fanming is the lead sponsor of 4 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Age between 18 and 80 years old - Surgery performed under general anesthesia for radical resection of lung cancer or lung cancer resection combined with lymph node dissection.
  • Pathological confirmation of primary lung cancer after surgery.
  • Duration of persistent dry cough after lung surgery ≥2 weeks.
  • Consciousness, ability to express opinions clearly, and voluntary signing of informed consent.

Exclusion criteria

Exclusion Criteria:

  • Patients diagnosed with acute respiratory system diseases within 1 month.
  • Patients diagnosed with pneumonia based on chest X-ray.
  • Patients with a history of asthma or tuberculosis.
  • Patients with uncontrolled hyperthyroidism, severe hypertension, heart disease, systemic infection, coagulation disorders (hypercoagulable state or bleeding tendency), or other severe systemic diseases.
  • Patients who have used steroid drugs within the past 3 months.
  • Patients who have taken angiotensin-converting enzyme inhibitors (ACEIs) within the past 6 months.
  • Patients with surgical incisions, skin allergies, wounds, or infections in the treatment area.
  • Patients who cannot tolerate transcutaneous acupoint electrical stimulation or withdraw during the procedure.
  • Patients with contraindications to transcutaneous electrical stimulation or implanted electrophysiological devices.
  • Patients who are pregnant or breastfeeding.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
84 participants (estimated)

Study arms

  • Experimental
    TEAS group

    The patient takes a sitting position, uses alcohol to wipe the skin at the selected acupoint, waits for it to dry, and then applies the electrode patch. Connect the percutaneous acupoint electric stimulator and provide transcutaneous acupoint electric stimulation, selecting a continuous wave at 2 Hz.

    Other: Transcutaneous Acupoint Electrical Stimulation (TAES)

  • Sham comparator
    Sham TEAS group

    The electrode patch is placed on the acupoint, similar to the TEAS group patients, but without starting the electric stimulation, and indicates to the patient that there will be no special sensation during the treatment process. The electrode is well protected during the operation and will not come off.

    Other: Transcutaneous Acupoint Electrical Stimulation (TAES)

Interventions

  • OtherTranscutaneous Acupoint Electrical Stimulation (TAES)

    Transcutaneous acupoint electrical stimulation (TAES) is a non-invasive treatment method that delivers gentle electrical pulses through the skin to specific acupuncture points on the body. This technique aims to mimic the effects of traditional acupuncture, providing a convenient and painless method of treatment.

06

What researchers measure

Primary outcomes

  1. LCQ-MC

    The questionnaire consists of 19 items, each of which is divided into 7 levels according to the severity, including the impact of chronic cough on the physiological domain (chest pain, cough, sputum, fatigue, sleep, hoarseness, etc.), psychological domain (feeling embarrassed, anxious, depressed, annoyed, etc.), and social domain (work, daily life, leisure activities, conversation, phone calls, interference with friends or family members). The score for each domain is the total score of each item in that domain divided by the number of questions (scored from 1 to 7), and the total score is the sum of the scores for the three domains (scored from 3 to 21). A higher score represents a better patient's health condition.

    Time frame: Prior to treatment (baseline), at the end of treatment (week 2), and 2 weeks after the end of treatment (week 4)

07

Study locations

1 of 1 sites recruiting
  • First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
    Tianjin, Tianjin Municipality 300193, China
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 8, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06548711
Lead sponsor
Kong Fanming
Responsible party
Kong Fanming (Director of Oncology Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine) — Sponsor-investigator
First posted
Aug 12, 2024
Start date
Apr 17, 2024
Primary completion
Apr 17, 2026 (estimated)
Completion
Jun 17, 2026 (estimated)
Last update
Sep 8, 2025

Study contacts

Fanming Kong, PhD
Contact
kongfanming08@163.com
+ 86 22 27986525

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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