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CompletedNCT06542510Updated Aug 7, 2024

The Impact of Working Night Shifts on Cardiac Autonomic Nervous Regulation During the Six-minute Walk Test in Nurses

An observational study in Autonomic Nervous System Imbalance, sponsored by Nanfang Hospital, Southern Medical University. Completed at 1 site in China. Open to female participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-08-07.

Sponsored by Nanfang Hospital, Southern Medical University · Observational

Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
35
Ages
18 Years to 60 Years
Sex
Female
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Study summary

To evaluate changes in heart rate variability (HRV) after the six-minute walk test (6MWT) in nurses following a night shift and explore the impact of night shift work on the regulation of the autonomic nervous system in the heart.

Thirty-five female nurses, with a mean age of 28.7 years (range 21.0-37.0 years), participated in this study. On the first and second mornings after a night shift, the nurses performed the 6MWT. During the test, electrocardiogram (ECG) signals, blood pressure, and walking distance were recorded simultaneously.

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Conditions studied

  • Autonomic Nervous System Imbalance

Keywords

  • heart rate variability; night shift; autonomic nervous system; six-minute walk test; nurses
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In context

Lead sponsor

Nanfang Hospital, Southern Medical University is the lead sponsor of 480 studies on the registry; 212 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

The participants were nurses from Nanfang Hospital of Southern Medical University who worked ward shifts. The nurses in this study had one night shift every 5-10 days, from 00:00 a.m. to 8:00 a.m., followed by 2-3 days off.

Inclusion criteria

  • Female nurses aged ≥ 18 years who had undergone annual physical examinations, did not have serious cardiopulmonary diseases, and were able to walk normally were considered for inclusion in the study.

Exclusion criteria

Exclusion Criteria:

  • (ⅰ) having children at home who require night care; (ⅱ) current pregnancy; (ⅲ) engaging in activities that significantly impact heart rate, such as sexual activity, 24 hours before and 24 hours after working night shifts; (ⅳ) history of thyroid dysfunction, hypertension, diabetes, coronary heart disease, etc.; (ⅴ) experiencing upper respiratory tract infection, fever, cough, diarrhea, or other illnesses within 1 week before the planned enrollment; (ⅵ) consuming coffee or strong tea, smoking, drinking alcohol, or using other substances that affect heart rate 3 days before the planned enrollment; (ⅶ) taking β-receptor blockers, sleeping pills, psychotropic drugs, or other medications that affect heart rate; and (ⅷ) judged by the investigator to be unsuitable for participation in this study.
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Study design

Observational model
Other
Time perspective
Prospective
Enrollment
35 participants (actual)
Patient registry
No

Interventions

  • Behavioralworking night shift

    working night shift

    Also known as: night shift

06

What researchers measure

Primary outcomes

  1. Delta HRV during the 6MWT

    On the first and second mornings after a night shift, the nurses performed the 6MWT.During the test, electrocardiogram (ECG) signals was recorded simultaneously.

    Time frame: 18 minutes

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Study locations

1 site
  • Nanfang Hospital, Southern Medical University
    Guangzhou, Guangdong 510515, China
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References and documents

Individual participant data

Plan to share: Yes — The data of the study are available from the corresponding author upon reasonable request.

Supporting information: Study protocol

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 7, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06542510
Lead sponsor
Nanfang Hospital, Southern Medical University
Responsible party
Sponsor
First posted
Aug 7, 2024
Start date
Jan 30, 2024
Primary completion
Apr 15, 2024
Completion
Apr 30, 2024
Last update
Aug 7, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2024. You cannot join it, but the record below documents what was studied.

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