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CompletedNCT06536907Updated Aug 5, 2024

Decompression of Odontogenic Cysts

An observational study in Odontogenic Cysts, Keratocysts of the Jaw and Cysts Dental, sponsored by Akdeniz University. Completed at 1 site in Turkey (Türkiye). Per ClinicalTrials.gov, last updated 2024-08-05.

Sponsored by Akdeniz University · Observational

Study type
Observational
Model
Case-control
Time perspective
Retrospective
Enrollment
39
Sex
All
01

Study summary

The aim of this case-control study is to evaluate the effects of decompression of cystic jaw lesions by means of comparing pre- and post-decompression histologic findings.

The main question it aims to answer is:

Does decompression of cystic jaw lesions alter the histologic diagnosis?

A retrospective analysis was performed based on the comparison of initial and final histologic diagnoses of patients with an odontogenic cystic lesion, that was surgically treated with decompression followed by a definitive surgery.

Read the detailed description

The study included patients with a histologic diagnosis of an odontogenic cystic lesion, that was surgically treated with decompression followed by a definitive surgery. The study was carried out retrospectively by means of evaluating records, surgical and histologic reports of patients. Pre- and post-decompression histologic findings were compared in effort to understand if decompression leads to alteration in histologic character and change in diagnoses of lesions.

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Conditions studied

  • Odontogenic Cysts
  • Keratocysts of the Jaw
  • Cysts Dental
  • Pathology

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Keywords

  • biopsy
  • diagnosis
  • keratocysts
  • odontogenic cysts
  • oral pathology
  • surgical decompression
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In context

Disease

1,382 studies on the registry are indexed under Disease; 612 are open to participants now.

This study's enrollment of 39 is below the median of 209 across 598 observational studies indexed under Disease.

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Lead sponsor

Akdeniz University is the lead sponsor of 296 studies on the registry; 62 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

The study included patients with a histologic diagnosis of an odontogenic cystic lesion, that was surgically treated with decompression followed by a definitive surgery.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • To have an initial diagnosis of an odontogenic cystic jaw lesion confirmed with an incisional biopsy.
  • The patients must have undergone decompression and, enucleation or enucleation and peripheral ostectomy after decompression period.

Exclusion criteria

Exclusion Criteria:

  • Previously treated patients
  • The patients with missing information in medical and/or dental records
  • The patients who did not adhere to follow-up protocol
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Study design

Observational model
Case-control
Time perspective
Retrospective
Enrollment
39 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Change in histologic diagnosis following decompression (yes/no)

    A comparison will be made between the initial histologic diagnosis and post-decompression definitive histologic diagnosis of the cystic jaw lesions

    Time frame: A decompression period ranging between 2 and 15 months

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Study locations

1 site
  • Akdeniz University
    Antalya, 07070, Turkey (Türkiye)
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References and documents

Publications

  • Rajendra Santosh AB. Odontogenic Cysts. Dent Clin North Am. 2020 Jan;64(1):105-119. doi: 10.1016/j.cden.2019.08.002. Epub 2019 Oct 18. PubMed 31735221 ↗
  • Wakolbinger R, Beck-Mannagetta J. Long-term results after treatment of extensive odontogenic cysts of the jaws: a review. Clin Oral Investig. 2016 Jan;20(1):15-22. doi: 10.1007/s00784-015-1552-y. Epub 2015 Aug 8. PubMed 26250795 ↗
  • Oliveros-Lopez L, Fernandez-Olavarria A, Torres-Lagares D, Serrera-Figallo MA, Castillo-Oyague R, Segura-Egea JJ, Gutierrez-Perez JL. Reduction rate by decompression as a treatment of odontogenic cysts. Med Oral Patol Oral Cir Bucal. 2017 Sep 1;22(5):e643-e650. doi: 10.4317/medoral.21916. PubMed 28809378 ↗
  • Mohanty S, Dabas J, Verma A, Gupta S, Urs AB, Hemavathy S. Surgical management of the odontogenic keratocyst: A 20-year experience. Int J Oral Maxillofac Surg. 2021 Sep;50(9):1168-1176. doi: 10.1016/j.ijom.2021.02.015. Epub 2021 Mar 2. PubMed 33663899 ↗
  • Anavi Y, Gal G, Miron H, Calderon S, Allon DM. Decompression of odontogenic cystic lesions: clinical long-term study of 73 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Aug;112(2):164-9. doi: 10.1016/j.tripleo.2010.09.069. Epub 2010 Dec 30. PubMed 21194990 ↗
  • Pogrel MA, Jordan RC. Marsupialization as a definitive treatment for the odontogenic keratocyst. J Oral Maxillofac Surg. 2004 Jun;62(6):651-5; discussion 655-6. doi: 10.1016/j.joms.2003.08.029. PubMed 15170272 ↗
  • Schlieve T, Miloro M, Kolokythas A. Does decompression of odontogenic cysts and cystlike lesions change the histologic diagnosis? J Oral Maxillofac Surg. 2014 Jun;72(6):1094-105. doi: 10.1016/j.joms.2013.12.028. Epub 2014 Jan 15. PubMed 24576437 ↗
  • Allon DM, Allon I, Anavi Y, Kaplan I, Chaushu G. Decompression as a treatment of odontogenic cystic lesions in children. J Oral Maxillofac Surg. 2015 Apr;73(4):649-54. doi: 10.1016/j.joms.2014.10.024. Epub 2014 Oct 31. PubMed 25631867 ↗
  • Berretta LM, Melo G, Mello FW, Lizio G, Rivero ERC. Effectiveness of marsupialisation and decompression on the reduction of cystic jaw lesions: a systematic review. Br J Oral Maxillofac Surg. 2021 Dec;59(10):E17-E42. doi: 10.1016/j.bjoms.2021.03.004. Epub 2021 Mar 23. PubMed 34749963 ↗
  • August M, Faquin WC, Troulis MJ, Kaban LB. Dedifferentiation of odontogenic keratocyst epithelium after cyst decompression. J Oral Maxillofac Surg. 2003 Jun;61(6):678-83; discussion 683-4. doi: 10.1053/joms.2003.50137. PubMed 12796876 ↗
  • Nakamura N, Mitsuyasu T, Mitsuyasu Y, Taketomi T, Higuchi Y, Ohishi M. Marsupialization for odontogenic keratocysts: long-term follow-up analysis of the effects and changes in growth characteristics. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Nov;94(5):543-53. doi: 10.1067/moe.2002.128022. PubMed 12424446 ↗
  • von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Bull World Health Organ. 2007 Nov;85(11):867-72. doi: 10.2471/blt.07.045120. PubMed 18038077 ↗
  • Castro-Nunez J. Decompression of Odontogenic Cystic Lesions: Past, Present, and Future. J Oral Maxillofac Surg. 2016 Jan;74(1):104.e1-9. doi: 10.1016/j.joms.2015.09.004. Epub 2015 Sep 21. PubMed 26428611 ↗
  • Mustansir-Ul-Hassnain S, Chandavarkar V, Mishra MN, Patil PM, Bhargava D, Sharma R. Histopathologic and immunohistochemical findings of odontogenic jaw cysts treated by decompression technique. J Oral Maxillofac Pathol. 2021 May-Aug;25(2):272-278. doi: 10.4103/0973-029X.325126. Epub 2021 Aug 31. PubMed 34703121 ↗
  • Castro-Nunez J, Wiscovitch AG, Porte JP, Wiscovitch J, Rivera B, Guerrero LM. Does active decompression of odontogenic keratocyst change the histologic diagnosis? Oral Maxillofac Surg. 2022 Jun;26(2):291-298. doi: 10.1007/s10006-021-00994-4. Epub 2021 Jul 29. PubMed 34324108 ↗
  • Awni S, Conn B. Decompression of keratocystic odontogenic tumors leading to increased fibrosis, but without any change in epithelial proliferation. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Jun;123(6):634-644. doi: 10.1016/j.oooo.2016.12.007. Epub 2016 Dec 30. PubMed 28377093 ↗
  • Rodu B, Tate AL, Martinez MG Jr. The implications of inflammation in odontogenic keratocysts. J Oral Pathol. 1987 Nov;16(10):518-21. doi: 10.1111/j.1600-0714.1987.tb00684.x. PubMed 3127567 ↗
  • Zhang L, Liu SL, Ye WM, Zheng J. STAT3 is a key pathway in primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst. Am J Transl Res. 2015 Oct 15;7(10):1860-9. eCollection 2015. PubMed 26692930 ↗

Individual participant data

Plan to share: Undecided

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jan 2015 to primary completion in Dec 2018, 47 months.

How these figures are worked out, and which studies are left out of them.

Registered
Jul 31, 2024
First posted
Aug 5, 2024
StartActual
Jan 1, 2015
Primary completionActual
Dec 31, 2018
CompletionActual
Sep 1, 2023
Last update
Aug 5, 2024
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 5, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06536907
Lead sponsor
Akdeniz University
Responsible party
Mehmet Ali Altay (Associate Professor, Akdeniz University) — Principal investigator
First posted
Aug 5, 2024
Start date
Jan 1, 2015
Primary completion
Dec 31, 2018
Completion
Sep 1, 2023
Last update
Aug 5, 2024

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2024. You cannot join it, but the record below documents what was studied.

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