An interventional study of Steinway Spirio M recording/player piano in Stress and Pain, sponsored by M.D. Anderson Cancer Center. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-12.
Sponsored by M.D. Anderson Cancer Center · Not applicable, Interventional, and Supportive care
The study plans to enroll a total of 132 patients. The goal of this study is to measure pre-and post-music intervention changes in patients' vital signs, serum- and plasma-level biomarkers by broad-spectrum proteomics analysis, metabolic analysis, and perceived pain, anxiety, and mood states as measured by validated questionnaires (STAI-S, POMS-SF, and VASP). We will collect demographic information on each participant. Participants will also complete the Brief Musical Experience Questionnaire (BMEQ) to investigate potential links between susceptibility to music-induced anxiolysis and prior musical training, preference and exposure.
Primary Objectives:
Secondary Objectives:
2,219 studies on the registry are indexed under Pain; 917 are open to participants now.
This study's planned enrollment of 132 is above the median of 70 across 1,904 interventional studies indexed under Pain.
Browse Pain studies →M.D. Anderson Cancer Center is the lead sponsor of 2,999 studies on the registry; 581 are open to participants now.
Of its 599 completed or terminated interventional studies of FDA-regulated products, 402 (67%) have results posted.
Counted across the registry records on this site, refreshed daily.
1) Patients undergoing neurosurgical procedures will be eligible to enroll in this study.
Exclusion Criteria
Patients will be screened for eligibility, enrolled in the study and randomized 1:1:1.
Other: Steinway Spirio M recording/player piano
Patients will be screened for eligibility, enrolled in the study and randomized 1:1:1.
Other: Steinway Spirio M recording/player piano
Patients will be screened for eligibility, enrolled in the study and randomized 1:1:1.
Other: Steinway Spirio M recording/player piano
Patients will be equally randomized into one of the three arms (simulated live music, recorded music, or no music) applying the random permutated block. Randomization will be conducted via an approved institutional database with the randomization list generated by the study statistician.
Stress and mood changes
Pre-post intervention changes in physiologic and perceived stress and mood changes by BP, STAI-S, VASP and POM-S.
Time frame: Through study cmpletion
Stress biomarkers
Proteomic and metabolomic analyses, in stress biomarkers and cytokines including IL-6, cortisol and epinephrine.
Time frame: Through study completion
BMEQ (Brief Music Experience Questionnaire)
Approximately 15 minutes to complete each time)
Time frame: Through study completion
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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M.D. Anderson Cancer Center