An interventional study of Air purifier in Air Pollution, Indoor, sponsored by Alaska Native Tribal Health Consortium. Recruiting at 1 site in United States. Open to participants aged Up to 5 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-02-27.
Sponsored by Alaska Native Tribal Health Consortium · Not applicable, Interventional, and Prevention
Alaska Native children experience a high burden of respiratory disease, especially those in the Yukon-Kuskokwim (YK) Delta. Studies have shown that things like wood stove use, poor ventilation, and indoor tobacco smoke exposure can lead to poor indoor air quality inside the children's homes. This leads to more frequent and more severe respiratory infections in children.
In the Yukon-Kuskokwim (YK) Delta, it's common for homes to have exposure to woodstoves and tobacco use. Both of these activities affect indoor air quality in homes. We know that high efficiency particulate air (HEPA) purifiers can reduce particulate matter and make air quality better. One way that we measure air quality is through particulate matter (PM2.5). One of the few studies that looked at this in the YK Delta found that PM2.5 levels that were nearly twice as high as homes with woodstoves in other states. We believe it is important to reduce the PM2.5 in YK Delta homes. However, the few studies that looked at HEPA purifiers in rural Alaska did not include homes where smokers lived.
We know that breathing air with PM2.5 harms the lungs. We also know that HEPA filters can reduce PM2.5, which can mean reducing cough and wheeze in people with chronic lung conditions. We want to learn how HEPA filters work in homes with woodstoves or where a smoker lives, as it's likely these homes may have more PM2.5 than other homes. We expect that using HEPA filters will make the indoor air better and will mean decreased respiratory symptoms.
We plan to include 15 households with a child less than 5 years old in the family. Households that join will be asked to:
When a child has a pulmonology visit, the nurse will give the family a study flyer and invite them to learn more about the study. Participants that complete the informed consent process will be asked to: set up study equipment in their homes, operate the study equipment and do a weekly report of the child's respiratory symptoms for 12 weeks, and return the air monitoring equipment to the study team.
Alaska Native Tribal Health Consortium is the lead sponsor of 5 studies on the registry; 3 are open to participants now.
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Exclusion Criteria:
Participants receive HEPA purifiers and air monitoring equipment to operate daily for 12-weeks.
Device: Air purifier
Winix HEPA air purifier
Indoor particulate matter (PM2.5) concentrations
Mean weekly home indoor particulate matter (PM2.5) concentrations
Time frame: 12-weeks
Reported symptom-free days
paired analysis of mean symptom-free days with no reported respiratory symptoms
Time frame: 12-weeks
Started Nov 2024 (actual). Primary completion is estimated for Apr 2026, 16 months after the start.
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Alaska Native Tribal Health Consortium