An interventional study of Whole body cooling and Non-cooling in Burn Injury, sponsored by University of Texas Southwestern Medical Center. Recruiting at 1 site in United States. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-10-21.
Sponsored by University of Texas Southwestern Medical Center · Not applicable, Interventional, and Prevention
This project will identify the efficacy of whole body skin wetting aimed to attenuate excessive elevations in internal body temperatures during physical activity in well-healed burn survivors. The investigators will conduct a randomized crossover design study. Non-burned control subjects, subjects who experienced burns covering \~20% to 40% of their body surface area, and subject having burns >40% of their body surface area will be investigated. Subjects will exercise in heated environmental conditions while receiving no cooling or whole body skin wetting.
719 studies on the registry are indexed under Burns; 145 are open to participants now.
This study's planned enrollment of 40 is close to the median of 40 across 524 interventional studies indexed under Burns.
Browse Burns studies →University of Texas Southwestern Medical Center is the lead sponsor of 990 studies on the registry; 201 are open to participants now.
Of its 135 completed or terminated interventional studies of FDA-regulated products, 100 (74%) have results posted.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria: Non-burn survivors
Exclusion Criteria (non-burned individuals):
Inclusion Criteria (burn survivors):
Exclusion Criteria (burn survivors):
Subjects will exercise for 60 minutes in a hot and dry environment while being exposed to no cooling.
Other: Non-cooling
Subjects will exercise for 60 minutes in a hot and dry environment while being exposed to whole body skin wetting.
Other: Whole body cooling
Subjects will exercise for 60 minutes in the indicated environmental condition while being exposed to whole body skin wetting. Skin wetting will be performed by spraying water onto the whole body throughout the exercise bout.
Subjects will exercise for 60 minutes in the indicated environmental condition while being exposed to no cooling modalities.
Core Temperature
During exercise, one's core body temperature will increase. This device will measure this increase in core body temperature throughout the exercise.
Time frame: Prior to and throughout the bout of exercise; an average of 90 minutes.
Mean Skin Temperature
Average skin temperature from six sites.
Time frame: Prior to and throughout the bout of exercise; an average of 90 minutes.
Rate Pressure Product
Obtained from heart rate and systolic blood pressure.
Time frame: Prior to and throughout the bout of exercise; an average of 90 minutes.
Whole body sweat rate
Whole body sweat rate will be measured from pre and post nude body mass measures.
Time frame: Before and after exercise. 2 min per measure.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Texas Southwestern Medical Center