An interventional study of Long Gn-RH agonist protocol - Intracytoplasmic Sperm Injection in Infertility, sponsored by University of Alexandria. Completed at 1 site in Egypt. Open to female participants aged 20 Years to 35 Years. Per ClinicalTrials.gov, last updated 2024-07-31.
Sponsored by University of Alexandria · Not applicable, Interventional, and Treatment
The aim of this study is to investigate the role of GDF-8 in regulating progesterone levels during controlled ovarian stimulation in patients undergoing ICSI-ET and to evaluate its effects on pregnancy rates.
The main questions are
participants will undergo ICSI-ET cycle using the long GnRH-agonist protocol and serum levels of GDF-8 and progesterone will be measured at three time-points during the trial: on day of hCG trigger administration, on day of oocyte pickup, and 14 days after embryo transfer
2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.
This study's enrollment of 42 is below the median of 120 across 1,698 interventional studies indexed under Infertility.
Browse Infertility studies →University of Alexandria is the lead sponsor of 57 studies on the registry; 5 are open to participants now.
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Exclusion Criteria:
Procedure: Long Gn-RH agonist protocol - Intracytoplasmic Sperm Injection
pituitary downregulation with GnRH agonist - ovarian stimulation with exogenous gonadotropin - hCG adminstration as trigger of oocyte maturation Oocyte retriveal via transvaginal ultrasound guided aspiration embryo transfer progesterone as luteal phase support
Clinical pregnancy
visualization of intra-uterine gestational sac with a pulsating fetal pole within 5 weeks of embryo transfer
Time frame: 5 weeks after embryo transfer
Serum Growth Differentiation Factor - 8 (GDF-8)
serum levels of GDF-8
Time frame: three time-points: on day of trigger, on day of OPU, and 14 days after ET
Plan to share: No
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This study is completed, as verified in Jul 2024. You cannot join it, but the record below documents what was studied.
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University of Alexandria