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CompletedNCT06517602Updated Jul 24, 2024

Effect of Moringa Oleifera Leaves on Glycemic Control of Women With Type 2 Diabetes

An interventional study of Supplementation of Moringa oleifera leaf powder in Type 2 Diabetes, sponsored by University of Milan. Completed at 1 site in Algeria. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-07-24.

Sponsored by University of Milan · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 4 years 8 months after the study started (first participant enrolled Nov 2019, registered Jul 2024).
Phase
Not applicable
Study type
Interventional
Enrollment
52
Allocation
Randomized
Ages
18 Years and older
Sex
Female
01

Study summary

The objective of this clinical trial was to understand whether supplementation of Moringa oleifera leaf powder improved glycemic management in Sahrawi women with type 2 diabetes living in refugee camps. The main question sought to be answered was:

  • Does daily supplementation of Moringa oleifera leaf powder, in addition to oral hypoglycemic therapy, improve glycosylated hemoglobin and fasting blood glucose?

Researchers compared Moringa supplementation with no Moringa consumption to see if Moringa oleifera worked to improve glycemic control.

Participants had to:

  • Take Moringa oleifera leaves daily or abstain from consuming Moringa for 3 months.
  • Consistently take prescribed oral hypoglycemic agents
  • Undergo clinical examinations and measurement of biochemical, metabolic and body composition parameters at the time of recruitment and at the end of the study.
02

Conditions studied

  • Type 2 Diabetes

Keywords

  • Moringa oleifera
  • Type 2 diabetes
  • Humans
  • Glucose
  • HbA1c
03

In context

Diabetes Mellitus, Type 2

10,371 studies on the registry are indexed under Diabetes Mellitus, Type 2; 1,406 are open to participants now.

This study's enrollment of 52 is below the median of 80 across 8,350 interventional studies indexed under Diabetes Mellitus, Type 2.

Browse Diabetes Mellitus, Type 2 studies →

Lead sponsor

University of Milan is the lead sponsor of 183 studies on the registry; 28 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
Female
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Diagnosis of type 2 diabetes for at least 1 year
  • Absence of advanced retinopathy, terminal renal failure, active diabetic ulcers, amputations, and heart failure
  • Treatment with only oral hypoglycemic drugs.

Exclusion criteria

Exclusion Criteria:

  • Diagnosis of type 1 diabetes
  • Pregnancy or lactation
  • Treatment with insulin.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
52 participants (actual)

Study arms

  • Experimental
    Moringa

    The experimental group received for 3 months a daily supplementation of 10g of Moringa oleifera leaf powder to consume within the two main meals.

    Dietary Supplement: Supplementation of Moringa oleifera leaf powder

  • No intervention
    Control

    The control group were asked to refrain from consuming Moringa oleifera leaves throughout the study period (3 months).

Interventions

  • Dietary supplementSupplementation of Moringa oleifera leaf powder

    Women in the experimental group were asked to consistently take the prescribed oral hypoglycemic therapy and to maintain their lifestyle and eating habits. In addition, for the duration of the study (3 months), the experimental group was provided with 10 g of Moringa oleifera leaf powder daily to be consumed with main meals.

06

What researchers measure

Primary outcomes

  1. Glycosylated hemoglobin (HbA1c)

    Time frame: Glycosylated hemoglobin was measured at recruitment and at the end of the study (three months)

  2. Fasting glucose

    Time frame: Fasting glucose was measured at recruitment and at the end of the study (three months)

Secondary outcomes

  1. BMI

    Time frame: BMI were measured at recruitment and at the end of the study (3 months)

  2. Waist circumference

    Time frame: Waist circumference were measured at recruitment and at the end of the study (3 months)

  3. Hip circumference

    Time frame: Hip circumference were measured at recruitment and at the end of the study (3 months)

  4. % body fat

    Time frame: % of body fat were measured at recruitment and at the end of the study (3 months)

  5. Blood pressure

    Systolic and diastolic blood pressure

    Time frame: Systolic and diastolic blood pressure were measured at recruitment and at the end of the study (3 months)

07

Study locations

1 site
  • Dispensaris of Edchedería, Bir Lehlu, Mahbes, and Farsia (Smara camp)
    Tindouf, Algeria
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 24, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06517602
Responsible party
Alberto Battezzati (Professor, University of Milan) — Principal investigator
First posted
Jul 24, 2024
Start date
Nov 7, 2019
Primary completion
Feb 23, 2020
Completion
Feb 23, 2020
Last update
Jul 24, 2024

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2024. You cannot join it, but the record below documents what was studied.

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