A Phase 1 interventional study of Magnesium Sulfate 20 MG/ML and Lidocaine IV in Intubation Complication, sponsored by Arsil Radiansyah. Completed at 1 site in Indonesia. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-07-24.
Sponsored by Arsil Radiansyah · Phase 1, Interventional, and Prevention
The sample was randomly divided into 3 groups consisting of patients who received Magnesium Sulfate 30 mg/Kg, Lidocaine 1.5 mg/Kg, and Control. These groups will be checked for hemodynamic changes and cortisol values.
The sample was randomly divided into 3 groups and divided into 3 groups consisting of patients who received Magnesium Sulfate 30 mg/Kg, Lidocaine 1.5 mg/Kg, and Control. The first group of patients was given Magnesium Sulfate 30 mg /kg diluted in 20 ml with NaCl 0.9%, labeled with code A, and given in 5 minutes with a syringe pump, The second group was given Lidocaine 1.5 mg/kg diluted in 20 ml with NaCl 0.9%, labeled with code B and given in 5 minutes with a syringe pump, The third group was given NaCl 0.9%, in a 20 ml syringe labeled with code C and given in 5 minutes with a syringe pump. After induction and intubation, patients were then recorded systolic blood pressure, diastolic blood pressure, MAP, and pulse at T1 (3 minutes), T2 (5 minutes), T3 (7 minutes), and T4 (10 minutes).
This is the only study on the registry with Arsil Radiansyah as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Sample will be given MgSO4 30mg/Kg Intravenous as a premedication drugs before intubation for all patients who had craniotomy surgery
Drug: Magnesium Sulfate 20 MG/ML
Sample will be given Lidocain 1.5mg/Kg Intravenous as a premedication drugs before intubation for all patients who had craniotomy surgery
Drug: Lidocaine IV
Sample will be given NaCl 0,9% Intravenous 20 ml as a premedication drugs before intubation for all patients who had craniotomy surgery
Drug: saline solution
Administered intravenously with a dose of 30 mg/kg
Also known as: Magnesium sulfate injection
Administered intravenously with a dose of 1.5mg/Kg
Also known as: Lidocaine
Administered intravenously with 20 ml
Also known as: NaCl 0,9% Solution
Systolic Blood Pressure
mmHg
Time frame: 1 month
Diastolic Blood Pressure
mmHg
Time frame: 1 month
Mean Arterial Pressure (MAP)
Estimated by using a formula in which the lower (diastolic) blood pressure is doubled and added to the higher (systolic) blood pressure and that composite sum then is divided by 3 to estimate MAP
Time frame: 1 month
Heart Rate
beats per minute
Time frame: 1 month
Cortisol Levels
Cortisol Levels in nmol/L
Time frame: 1 month
Documents are hosted by the registry — open the source record to download them.
Plan to share: No
This study is completed, as verified in Jul 2024. You cannot join it, but the record below documents what was studied.
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