ClinicalTrials.gg
Status unknownNCT06509633Updated Jul 19, 2024

Effects of Pain Neuroscience Education and Standard Rehabilitation Regime in Patients of Carpal Tunnel Syndrome

An interventional study of Pain Neuroscience education and standard rehabilitation regime and standard Rehabilitation regime in Wrist Injuries and Carpal Tunnel Syndrome, sponsored by Riphah International University. Status unknown at 1 site in Pakistan. Open to female participants aged 20 Years to 50 Years. Per ClinicalTrials.gov, last updated 2024-07-19.

Sponsored by Riphah International University · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Jul 2024), so the status shown — last known as Recruiting — may be out of date.

From the registry’s dates

  • Registered 5 months after the study started (first participant enrolled Feb 2024, registered Jul 2024).
Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
20 Years to 50 Years
Sex
Female
01

Study summary

The aim of this study is to check the effects of Pain Neuroscience education and standard rehabilitation regime in patients of carpal tunnel syndrome.

Read the detailed description

In 2017 a stud assessed effectiveness of standard conservative protocol of CTS and nerve mobilization along with and without PNE and documented that standard conservative care seems to be the most appropriate option for pain relief, although neuroscience education might be a complementary option to accelerate recovery of function. More high-quality research is still necessary to determine its effectiveness and the subgroups of patients who may respond better to this treatment.

In 2019 a study was done to assess the effect of PNE and standard rehabilitation exercises on the 41 patients of CTS. The experimenting group was given one session of PNE plus exercises and the control group was given exercise therapy only. Patients were randomly allocated and double blinded. The analysis of study showed better results with experimental group rather than control group.

Many studies have found the effects of standard rehabilitation of Carpal Tunnel syndrome and their results in controlling pain and dysfunction. However as per researchers' knowledge little literature is available on effects of pain neuroscience education and standard rehabilitation regime in carpal tunnel syndrome. Therefore, this study6 is going to determine the effects of effectiveness of Pain Neuroscience education and standard rehabilitation regime in patients of carpal tunnel syndrome.

02

Conditions studied

  • Wrist Injuries
  • Carpal Tunnel Syndrome

Keywords

  • Carpal tunnel syndrome
  • Compression
  • Pain neuroscience education
  • Median nerve
03

In context

Wrist Injuries

42 studies on the registry are indexed under Wrist Injuries; 12 are open to participants now.

This study's planned enrollment of 30 is below the median of 60 across 27 interventional studies indexed under Wrist Injuries.

Browse Wrist Injuries studies →

Lead sponsor

Riphah International University is the lead sponsor of 2,176 studies on the registry; 637 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 50 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • age between 20_40 years old.
  • Medical diagnosis of moderate to severe CTS.
  • Symptoms of CTS since 1month
  • Unilateral or bilateral symptoms
  • Availability and access to the hospital.

Exclusion criteria

Exclusion Criteria:

  • Inability to understand instructions, neurological conditions of the central nervous system (e.g. stroke, spinal cord injury)
  • Patients on treatment with alternative therapies
  • Previous participation in a research program
  • Previous surgery on the affected upper limb
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
30 participants (estimated)

Study arms

  • Experimental
    Pain Neuroscience education and Standard Rehabilitation regime

    Patients will get standard treatment of CTS, which is nerve gliding, stretchings of forearm and wrist muscles and wrist mobilization along with pain neuroscience education.

    Other: Pain Neuroscience education and standard rehabilitation regime

  • Active comparator
    standard Rehabilitation regime

    Patient will get only nerve gliding and wrist forearm muscle stretching exercises.

    Other: standard Rehabilitation regime

Interventions

  • OtherPain Neuroscience education and standard rehabilitation regime

    Median nerve gliding exercises, wrist and forearm muscle stretches, wrist mobilizations and finger joint mobilizations

    Also known as: Standard Rehabilitation regime

  • Otherstandard Rehabilitation regime

    standard Rehabilitation regime

06

What researchers measure

Primary outcomes

  1. Numeric pain rate scale (NPRS)

    Patient level of pain will be assessed using this scale. This scale ranges from 0 to 10. 0 indicates "no pain" and 10 indicates "worst pain.

    Time frame: 4th week

Secondary outcomes

  1. Pain Catastrophizing Scale (PCS)

    The Pain Catastrophizing Scale (PCS) was used to measure catastrophic thinking in response to pain through 13 statements with four possible options, from 1 "not at all" to 4 "all the time".

    Time frame: 4th week

Other outcomes

  1. Boston Carpal Tunnel Questionnaire (BCTQ)

    BCTQmeasures self reported functional status and severity of symptom. The BCTQ-SSS consists of 11 questions, each question provides 5 response choices, from 1 (no symptoms) to 5 (most severe/often).

    Time frame: 4th week

  2. Goniometer

    The range of motions like flexion extension radial deviation and ulnar deviation of wrist will be measured by Goniometer.

    Time frame: 4th week

07

Study locations

1 of 1 sites recruiting
  • Absaar medical center
    Lahore, Punjab Province 56300, Pakistan
    Recruiting
08

References and documents

Publications

  • Werner RA, Andary M. Electrodiagnostic evaluation of carpal tunnel syndrome. Muscle Nerve. 2011 Oct;44(4):597-607. doi: 10.1002/mus.22208. PubMed 21922474 ↗
  • Genova A, Dix O, Saefan A, Thakur M, Hassan A. Carpal Tunnel Syndrome: A Review of Literature. Cureus. 2020 Mar 19;12(3):e7333. doi: 10.7759/cureus.7333. PubMed 32313774 ↗
  • Nunez-Cortes R, Espinoza-Ordonez C, Pommer PP, Horment-Lara G, Perez-Alenda S, Cruz-Montecinos C. A single preoperative pain neuroscience education: Is it an effective strategy for patients with carpal tunnel syndrome? Med Hypotheses. 2019 May;126:46-50. doi: 10.1016/j.mehy.2019.03.013. Epub 2019 Mar 22. PubMed 31010499 ↗
  • Nunez-Cortes R, Cruz-Montecinos C, Torreblanca-Vargas S, Tapia C, Gutierrez-Jimenez M, Torres-Gangas P, Calatayud J, Perez-Alenda S. Effectiveness of adding pain neuroscience education to telerehabilitation in patients with carpal tunnel syndrome: A randomized controlled trial. Musculoskelet Sci Pract. 2023 Oct;67:102835. doi: 10.1016/j.msksp.2023.102835. Epub 2023 Jul 28. PubMed 37572618 ↗
  • Ballestero-Perez R, Plaza-Manzano G, Urraca-Gesto A, Romo-Romo F, Atin-Arratibel MLA, Pecos-Martin D, Gallego-Izquierdo T, Romero-Franco N. Effectiveness of Nerve Gliding Exercises on Carpal Tunnel Syndrome: A Systematic Review. J Manipulative Physiol Ther. 2017 Jan;40(1):50-59. doi: 10.1016/j.jmpt.2016.10.004. Epub 2016 Nov 11. PubMed 27842937 ↗
  • Bulow K, Lindberg K, Vaegter HB, Juhl CB. Effectiveness of Pain Neurophysiology Education on Musculoskeletal Pain: A Systematic Review and Meta-Analysis. Pain Med. 2021 Apr 20;22(4):891-904. doi: 10.1093/pm/pnaa484. PubMed 33764394 ↗
  • Louw A, Puentedura EJ, Zimney K, Schmidt S. Know Pain, Know Gain? A Perspective on Pain Neuroscience Education in Physical Therapy. J Orthop Sports Phys Ther. 2016 Mar;46(3):131-4. doi: 10.2519/jospt.2016.0602. PubMed 26928735 ↗
  • Ziegler AM, Minkalis AL, Langdon ER, Vining R. Learning the neurobiology of pain: A scoping review of pain education from an instructional design perspective. Patient Educ Couns. 2022 Jun;105(6):1379-1401. doi: 10.1016/j.pec.2021.09.021. Epub 2021 Sep 14. PubMed 34579995 ↗
  • Lopez-de-Uralde-Villanueva I, Fernandez-de-Las-Penas C, Cleland JA, Cook C, de-la-Llave-Rincon AI, Valera-Calero JA, Plaza-Manzano G. Minimal Clinically Important Differences in Hand Pain Intensity (Numerical Pain Rate Scale) and Related-Function (Boston Carpal Tunnel Questionnaire) in Women With Carpal Tunnel Syndrome. Arch Phys Med Rehabil. 2024 Jan;105(1):67-74. doi: 10.1016/j.apmr.2023.07.018. Epub 2023 Aug 13. PubMed 37582474 ↗
  • Sullivan MJ, Bishop SR, Pivik J. The pain catastrophizing scale: development and validation. Psychological assessment. 1995;7(4):524.
  • Levine DW, Simmons BP, Koris MJ, Daltroy LH, Hohl GG, Fossel AH, Katz JN. A self-administered questionnaire for the assessment of severity of symptoms and functional status in carpal tunnel syndrome. J Bone Joint Surg Am. 1993 Nov;75(11):1585-92. doi: 10.2106/00004623-199311000-00002. PubMed 8245050 ↗

Individual participant data

Plan to share: No

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Started Feb 2024 (actual). Primary completion is estimated for Oct 2024, 8 months after the start.

How these figures are worked out, and which studies are left out of them.

Registered
Jul 15, 2024
First posted
Jul 19, 2024
StartActual
Feb 1, 2024
Primary completionEst.
Oct 10, 2024
CompletionEst.
Nov 10, 2024
Last update
Jul 19, 2024
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jul 19, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06509633
Responsible party
Sponsor
First posted
Jul 19, 2024
Start date
Feb 1, 2024
Primary completion
Oct 10, 2024 (estimated)
Completion
Nov 10, 2024 (estimated)
Last update
Jul 19, 2024

Study contacts

Imran Amjad
Contact
Imran.amjad@riphah.edu.pk
03324390125
Saba khan
principal investigator · Riphah International University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is status unknown, as verified in Jul 2024. You cannot join it, but the record below documents what was studied.

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