An interventional study of Questionnaire and Beighton test in Women, Tibial Translation and Hormone, sponsored by Centre Hospitalier Universitaire de Nice. Completed at 1 site in France. Open to female participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-10.
Sponsored by Centre Hospitalier Universitaire de Nice · Not applicable, Interventional, and Prevention
Women are recognized as being at greater risk of ACL injury, with a risk 6 times higher than that of men. Hyperlaxity is a risk factor for ACL injury, but the pathophysiological basis for this is poorly studied. Hormonal impregnation and certain periods of the menstrual cycle (ovulatory phase) are risk factors for ACL injury. It therefore seems interesting to study the influence of hormonal impregnation on ligament laxity. To date, to our knowledge, no study has investigated such a relationship.
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Exclusion Criteria:
For women on estrogen-progestin contraception: * Correct use of the estrogen-progestin pill in accordance with AMM Or wearing a vaginal ring according to AMM protocol Or wearing a contraceptive skin patch according to AMM protocol * Regular cycles of 26 to 33 days
Other: Questionnaire · Other: Beighton test · Other: Lachman Test
For women on progestin-only contraception: o Continuous use of the micro-progestogen or progestogen pill Or subcutaneous hormonal implant, Or a progesterone intrauterine device Or dienogest-type contraception
Other: Questionnaire · Other: Beighton test · Other: Lachman Test
For women without hormonal contraception : * No method of contraception Or copper intrauterine device * Regular cycles of 26 to 33 days
Other: Questionnaire · Other: Beighton test · Other: Lachman Test
Questionnaires on contraception and sports activities
A popular screening technique for hypermobility. It consists of a nine-point scale requiring the performance of five maneuvers, four passive bilateral and one active unilateral.
To perform this test, place your patient in a supine position and bring your patient's test leg to 30 degrees of flexion. Fix the femur with the other hand. Put the tibia in slight external rotation, then try to translate it forwards. This test is positive if you feel a soft or limp end or if the anterior part.
Change of anterior tibial translation of the knee with progestin-only hormonal contraception
To show that taking progestin-only hormonal contraception reduces anterior tibial translation of the knee compared with other types of contraception. Anterior tibial knee translation will be considered representative of anterior knee laxity in women on hormonal contraception, using the 30° Lachman test measured with a Lachmeter® digital arthrometer (bilateral examination repeated 3 times on each knee). The degree of laxity is assessed using the international IKDC classification: * Grade A 0 to 2 mm = normal * Grade B 3 to 5 mm = almost normal * Grade C 6 to 10 mm = abnormal * Grade D \> 10 mm = severely abnormal
Time frame: 24 months
Change of anterior tibial translation of the knee with progestin-only hormonal contraception or estrogen-only contraception.
To show that taking progestin-only or estrogen-only contraception reduces anterior tibial translation of the knee compared with not taking hormonal contraception. Anterior tibial knee translation will be considered representative of anterior knee laxity in women on hormonal contraception, using the 30° Lachman test measured with a Lachmeter® digital arthrometer (bilateral examination repeated 3 times on each knee). The degree of laxity is assessed using the international IKDC classification: * Grade A 0 to 2 mm = normal * Grade B 3 to 5 mm = almost normal * Grade C 6 to 10 mm = abnormal * Grade D \> 10 mm = severely abnormal
Time frame: 24 months
Anterior knee laxity at D14 and D25 of the cycle
Compare anterior tibial knee translation measured at D14 of the menstrual cycle with that measured at D25 of the menstrual cycle. Anterior tibial knee translation will be considered representative of anterior knee laxity in women on hormonal contraception, using the 30° Lachman test measured with a Lachmeter® digital arthrometer (bilateral examination repeated 3 times on each knee). The degree of laxity is assessed using the international IKDC classification: * Grade A 0 to 2 mm = normal * Grade B 3 to 5 mm = almost normal * Grade C 6 to 10 mm = abnormal * Grade D \> 10 mm = severely abnormal
Time frame: 14 or 25 days
Variable of height influencing anterior tibial knee translation
Independent factors of ligament laxity in study women (height in meters) will be requested or measured during V1 of the study.
Time frame: 24 months
Variable of weight influencing anterior tibial knee translation
Independent factors of ligament laxity in study women (weight in kilograms) will be requested or measured during V1 of the study.
Time frame: 24 months
Variable of age influencing anterior tibial knee translation
Independent factors of ligament laxity in study women (age in years) will be requested or measured during V1 of the study.
Time frame: 24 months
Variable of duration of contraceptive use influencing anterior tibial knee translation
Independent factors of ligament laxity in study women (duration of contraceptive use in days) will be requested or measured during V1 of the study.
Time frame: 24 months
Variable of cycle lenght influencing anterior tibial knee translation
Independent factors of ligament laxity in study women (cycle length in days) will be requested or measured during V1 of the study.
Time frame: 24 months
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Universitaire de Nice