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RecruitingNCT06498310IMI-CARTUpdated Jul 12, 2024

Retrospective Study of Invasive Fungal Infections With Filamentous Fungi in Heart Transplant Patients

An observational study in Invasive Fungal Infections, sponsored by University Hospital, Strasbourg, France. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-07-12.

Sponsored by University Hospital, Strasbourg, France · Observational

From the registry’s dates

  • Primary completion was expected by Nov 2025, 1 year ago, but the record still lists the study as recruiting.
  • Started Nov 2023; still recruiting 3 years later.
Study type
Observational
Model
Case-control
Time perspective
Retrospective
Enrollment
100
Ages
18 Years and older
Sex
All
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Study summary

Invasive filamentous fungal infections (aspergillosis, scedosporiosis, mucormycosis, fusarium wilt) are common and serious in immunocompromised subjects and particularly organ transplant patients. There is little recent data in heart transplantation, particularly on the incidence and risk factors of fungal infections. . It is therefore important to have recent data on incidence, risk and prognostic factors in order to improve the management of this severe complication.

02

Conditions studied

  • Invasive Fungal Infections

Keywords

  • Invasive Fungal Infections
  • Filamentous fungi
  • Heart transplant
  • Fungal infections
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In context

Invasive Fungal Infections

136 studies on the registry are indexed under Invasive Fungal Infections; 33 are open to participants now.

This study's planned enrollment of 100 is below the median of 125 across 66 observational studies indexed under Invasive Fungal Infections.

Browse Invasive Fungal Infections studies →

Lead sponsor

University Hospital, Strasbourg, France is the lead sponsor of 999 studies on the registry; 358 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Adult patient ≥18 years old having heart transplant and invasive fungal infection with filamentous fungi during the period from January 1, 2008 to December 31, 2022

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adult patient ≥18 years old
  • Heart transplant
  • Invasive fungal infection with filamentous fungi during the period from January 1, 2008 to December 31, 2022
  • Proven or probable infection with filamentous fungi according to EORTC/MSGERC criteria (20):

    • Invasive aspergillosis
    • Mucormycosis
    • Fusarium wilt
    • Scedosporiosis
    • Other filamentous fungus infection
  • Subject who has not expressed, after information, his opposition to the reuse of his data for the purposes of this research.

Exclusion criteria

Exclusion Criteria:

  • Patient having expressed his opposition to participating in the study
  • Patient not having a liver transplant
  • Subject under guardianship, curatorship or safeguard of justice.
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Study design

Observational model
Case-control
Time perspective
Retrospective
Enrollment
100 participants (estimated)
Patient registry
No
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What researchers measure

Primary outcomes

  1. To identify the incidence, risk factors and prognostic factors associated with invasive fungal infections caused by filamentous fungi in heart transplant patients.

    1. Incidence: number of cases of invasive fungal infection compared to the number of heart transplant patients per year in the study centers 2. Risk factors: Case-control study. Clinical, microbiological or radiological factors statistically associated with cases of invasive fungal infection compared to controls. 3. Prognostic factors: Clinical, microbiological or radiological factors of invasive fungal infections associated with mortality at the 12th week.

    Time frame: Up to 2 years

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Study locations

1 of 1 sites recruiting
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 12, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06498310
Responsible party
Sponsor
First posted
Jul 12, 2024
Start date
Nov 8, 2023
Primary completion
Nov 2025 (estimated)
Completion
Nov 8, 2025 (estimated)
Last update
Jul 12, 2024

Study contacts

François DANION, MD
Contact
francois.danion@chru-strasbourg.fr
33 3 69 55 15 88

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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