An interventional study of High-intensity interval training and Moderate intensity continuous training in Chronic Stroke, sponsored by National Yang Ming Chiao Tung University. Recruiting at 1 site in Taiwan. Open to participants aged 18 Years to 69 Years. Per ClinicalTrials.gov, last updated 2024-09-19.
Sponsored by National Yang Ming Chiao Tung University · Not applicable, Interventional, and Treatment
Both gait and cardiovascular dysfunction are primary factors limiting community ambulation for stroke individuals. Increased gait variability and asymmetry contributes to a higher risk of falls, leading to reduced physical activity, decreased cardiorespiratory endurance, and increased walking economy and sympathetic nervous system activity, thereby potentially triggering secondary strokes. Previous studies have primarily focused on the significant improvements in walking endurance and speed with high-intensity interval training (HIIT) on a treadmill, leaving a gap in understanding the effects of HIIT on oxygen uptake efficiency slope (OUES) and gait quality for stroke individuals using a stationary bicycle ergometer with exergaming. Therefore, this study aims to investigate the effects of HIIT using a stationary bicycle ergometer on improving cardiorespiratory fitness and gait quality in individuals with chronic stroke.
7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.
This study's planned enrollment of 32 is below the median of 50 across 5,369 interventional studies indexed under Stroke.
Browse Stroke studies →National Yang Ming Chiao Tung University is the lead sponsor of 201 studies on the registry; 58 are open to participants now.
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Exclusion Criteria:
The intervention is a 42-minute session and 3-sessions/week, totaling 8 weeks.
Other: High-intensity interval training
The intervention is a 45-minute session and 3-sessions/week, totaling 8 weeks.
Other: Moderate intensity continuous training
Training on a stationary bike and integrated with exergame (Jbike, JACFIT, USA), the exercise games connect to a map in the app through sensors, allowing players from different countries to ride together and complete the map, thus increasing the diversity of the training, including a warm-up and cool-down at 30% HRR for 5 minutes each. Perform HIIT with 5 intervals at 80% heart rate reserve (HRR), each interval lasting 4 minutes, with 3-minute intervals at 40% HRR between each interval.
Training on a stationary bike and integrated with exergame (Jbike, JACFIT, USA), the exercise games connect to a map in the app through sensors, allowing players from different countries to ride together and complete the map, thus increasing the diversity of the training, including a warm-up and cool-down at 30% HRR for 5 minutes each. Perform continuous exercise at 59% HRR for 35 minutes.
Oxygen uptake efficiency slope (OUES): cardiovascular fitness
Perform symptom-limited exercise testing on a stationary bike using an incremental protocol. Maintain a pedal rate of 50-60 rpm, starting with an initial resistance of 50 watts. Increase the resistance by 25 watts every 2 minutes until the participant experiences exercise discomfort. OUES = Oxygen uptake / Log10 \* Minute ventilation
Time frame: Change from baseline at 8 weeks
Gait variability
Using GAITRite system to measure coefficient of variation. During the assessment, participants will be asked to walk three times. The mean and standard deviation will be used to calculate the coefficient of variation (CV). CV = standard deviation / mean \* 100%
Time frame: Change from baseline at 8 weeks
Gait symmetry index (SI)
Use the GAITRite system to assess the symmetry of spatial and temporal gait parameters. During the assessment, participants will be asked to walk three times. Calculate the symmetry index using the mean. SI = (affected side - unaffected side) / (1/2 \* (affected side + unaffected side)) \* 100%
Time frame: Change from baseline at 8 weeks
Peak oxygen consumption (VO2peak): cardiovascular fitness
Perform symptom-limited exercise testing on a stationary bike using an incremental protocol. Maintain a pedal rate of 50-60 rpm, starting with an initial resistance of 50 watts. Increase the resistance by 25 watts every 2 minutes until the participant experiences exercise discomfort.
Time frame: Change from baseline at 8 weeks
Minute ventilation (VE) / carbon dioxide production (VCO2) slope: cardiovascular fitness
Perform symptom-limited exercise testing on a stationary bike using an incremental protocol. Maintain a pedal rate of 50-60 rpm, starting with an initial resistance of 50 watts. Increase the resistance by 25 watts every 2 minutes until the participant experiences exercise discomfort. VE/VCO2 slope = minute ventilation / carbon dioxide production
Time frame: Change from baseline at 8 weeks
Heart rate recovery (HRR): cardiovascular fitness-
Perform symptom-limited exercise testing on a stationary bike using an incremental protocol. Maintain a pedal rate of 50-60 rpm, starting with an initial resistance of 50 watts. Increase the resistance by 25 watts every 2 minutes until the participant experiences exercise discomfort. HRR = peak heart rate - heart rate after one minute
Time frame: Change from baseline at 8 weeks
Blood pressure (BP): cardiovascular fitness
Perform symptom-limited exercise testing on a stationary bike using an incremental protocol. Maintain a pedal rate of 50-60 rpm, starting with an initial resistance of 50 watts. Increase the resistance by 25 watts every 2 minutes until the participant experiences exercise discomfort.
Time frame: Change from baseline at 8 weeks
6 minutes walking distance (6MWD): cardiovascular fitness
For the 6MWD, participants are asked to walk as fast as possible along a 30-meter corridor. During the test, heart rate and blood oxygen saturation level are continuously monitored. Record heart rate, blood pressure, blood oxygen saturation level, RPE, and total walking distance before and after the test.
Time frame: Change from baseline at 8 weeks
International Physical Activity Questionnaire (IPAQ) - Taiwan Physical Activity Questionnaire (Short Form)
The IPAQ is a self-reported instrument assesses the time spent in the past 7 days on activities including work, housework, gardening/balcony work, commuting, leisure, and exercise. Total time spent per week is multiplied by the metabolic equivalent (MET) and summed to present the total MET-minutes per week. Physical activity intensity is classified into walking (3.3 METs), moderate (4.0 METs), and vigorous (8.0 METs).
Time frame: Change from baseline at 8 weeks
Plan to share: Undecided
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