An observational study in Malignant Glioma, sponsored by Mayo Clinic. Recruiting at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-03.
Sponsored by Mayo Clinic · Observational
This study evaluates imaging methods for monitoring neural and electrical activity in the brain for improving clinical diagnosis.
PRIMARY OBJECTIVES:
I. Optimize pulse sequence acquisitions for diffusion imaging on clinical MRI vendor systems.
II. Develop image-based MRI models (including diffusion-based MRI) that accurately depict the multi-regional electrical properties in the brain (e.g., resistivity, current) to inform of neural integrity and function (including white matter tract integrity) in diseased and non-diseased states.
III. Compare/correlate image-based MRI models (e.g., diffusion) with existing structural, physiologic, and functional MRI methods (e.g., tensor imaging, fMRI, DSC-MRI, etc).
IV. Further train image-based models/measurements with loco-regional benchmarks including (but not exclusive to) electrophysiologic monitoring, functional and structural tissue assays (from available biopsies), and correlative clinical features (e.g., histology, outcomes, treatment, etc).
OUTLINE: This is an observational study.
Participants complete a survey and undergo MRI on study.
1,397 studies on the registry are indexed under Glioma; 351 are open to participants now.
This study's planned enrollment of 120 is above the median of 88 across 238 observational studies indexed under Glioma.
Browse Glioma studies →Mayo Clinic is the lead sponsor of 3,218 studies on the registry; 670 are open to participants now.
Of its 445 completed or terminated interventional studies of FDA-regulated products, 313 (70%) have results posted.
Counted across the registry records on this site, refreshed daily.
Healthy volunteers and clinical neuro-oncology subjects with high grade glioma
Exclusion Criteria:
Participants complete a survey and undergo MRI on study.
Other: Non-Interventional Study
Non-interventional study
Identify diffusion MRI metrics [using conductivity tensor imaging (CTI)] that inform of regional electrical properties in the brain
At least 4 normal white matter regions of the brain will be analyzed. Fractional anisotropy (FA) and optimized diagnostic imaging (ODI) values will be compared to determine alignment within normal healthy white matter tracts (e.g. cortical spinal tract, corpus callosum).
Time frame: Baseline
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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