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CompletedNCT06432192ApoDiagUpdated Apr 30, 2025

A Prospective, Monocentric Clinical Study for the Validation of in Vitro Diagnostic Tests Developed by Firalis

An observational study in Genetic Health Risks, sponsored by Firalis SA. Completed at 2 sites in France. Open to participants aged 18 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-04-30.

Sponsored by Firalis SA · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
1,474
Ages
18 Years to 85 Years
Sex
All
01

Study summary

Firalis SA and its affiliate Amoneta Diagnostics SAS are developing novel in-vitro-diagnostic (IVD) tests for diverse diagnostic applications for major human diseases, including cardiovascular, and neurodegenerative disorders. These tests detect several gene mutations related to the above-mentioned pathologies. The development of IVD tools requires the evaluation of analytical parameters including biomarker stability.

The present specific study therefore aims to collect whole blood samples in PAXgene DNA tubes to complete the analytical validation of IVD tools and the evaluation of the stability of the DNA in PAXgene DNA tubes and the reagents in the IVD tools.

02

Conditions studied

  • Genetic Health Risks

Keywords

  • Polygenic risk
  • APOE, Apolipoprotein
  • Neurodegenerative disorders
  • Dementia
  • Alzheimer disease
  • Genetic risks
03

Who can participate

Ages eligible
18 Years to 85 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Healthy donors

Inclusion criteria

  • Donors who sign the informed consent forms for sample collection and for genotyping.
  • Adults, both genders, aged 18-85 years.
  • Not under any administrative or legal supervision

Exclusion criteria

Exclusion Criteria:

  • Anyone who did not sign the Informed Consent form.
  • Subjects aged below 18 years and older than 85 years are excluded.
  • Pregnant, parturient and nursing women are excluded
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
1,474 participants (actual)
Patient registry
No

Groups and cohorts

  • APOE E

    The cohort will be genotyped to determine the phenotype of the APOE allele

    Diagnostic Test: APO-Easy

Interventions

  • Diagnostic testAPO-Easy

    Testing for the APOE genotype using the APO-Easy Genotyping test

05

What researchers measure

Primary outcomes

  1. APOE Genotype

    Blood samples will be collected to establish the feasibility of detecting several gene mutations associated with the risk of Alzheimer's disease/ Cardiovascular disorder and validation of analytical parameters

    Time frame: Baseline

Secondary outcomes

  1. Specimen stability

    Blood samples will be collected to establish the stability of PAXgene DNA samples at different timepoints after storage at -20° and -80°C.

    Time frame: Baseline, 24hrs, 5 days, 28 days, 3 months, 12 months, 24 months

06

Study locations

2 sites
  • EFS GEST
    Nancy, 54100, France
  • EFS GEST
    Strasbourg, 67000, France
07

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT06432192
Lead sponsor
Firalis SA
Responsible party
Sponsor
First posted
May 29, 2024
Start date
Jan 2, 2024
Primary completion
Mar 25, 2025
Completion
Mar 25, 2025
Last update
Apr 30, 2025

Study contacts

Huseyin Firat, MD PhD
study director · Firalis SA
Lucas Pham-Van, PhD
study chair · Firalis SA
Joanna Michel
study chair · Firalis SA
Sthepanie Boutillier, PhD
study director · Firalis SA

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Sep 2024. You cannot join it, but the record below documents what was studied.

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