An interventional study of Plain Water and Liquid IV Hydration Multiplier in Dehydration, sponsored by Arizona State University. Completed at 1 site in United States. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-08-28.
Sponsored by Arizona State University · Not applicable, Interventional, and Other
It is well established that rehydration with a carbohydrate-electrolyte solution is more effective in comparison to plain water. This is primarily based on the sodium-glucose co transporter, based on which the world health organization has based its oral rehydration solution recommendations. Also, rehydration with a solution that includes sodium and glucose plasma osmolality should not drop as much as it happens during rehydration with water. As a result, we should have higher fluid intake due to higher thirst perception and lower urinary output due to higher levels of vasopressin.
The present study aims to examine the effectiveness of a electrolyte-glucose drink on rehydration following exercise-induced dehydration.
201 studies on the registry are indexed under Dehydration; 28 are open to participants now.
This study's enrollment of 20 is below the median of 43 across 145 interventional studies indexed under Dehydration.
Browse Dehydration studies →Arizona State University is the lead sponsor of 238 studies on the registry; 42 are open to participants now.
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Exclusion Criteria:
Rehydration with low mineral content bottle water
Other: Plain Water
Drink with 22 grams of carbohydrate, 1020 milligrams of sodium, and 760 milligrams of potassium per liter. Hydration multiplier liquid IV
Other: Liquid IV Hydration Multiplier
10 grams of carbohydrate, 1060 milligrams of sodium, and 760 milligrams of potassium per liter. Sugar free Liquid IV
Other: Liquid IV Sugar Free
Plain water without calories, sweetener, or electolytes
Drink with 22 grams of carbohydrate, 1020 milligrams of sodium, and 760 milligrams of potassium per liter. Hydration multiplier liquid IV
10 grams of carbohydrate, 1060 milligrams of sodium, and 760 milligrams of potassium per liter. Sugar free Liquid IV
Total fluid intake
Total amount of fluid ingested
Time frame: 4 hours of rehydration
Net fluid balance
amount of water retained during the rehydration period
Time frame: at 4 hours of the rehydration period
Net fluid balance
amount of water retained during the rehydration period
Time frame: at 3 hours of the rehydration period
Rate of absorption
The rate of Deuterium appearance in the blood during 30 minutes of rehydration
Time frame: during the first 30 minutes of rehydration
Rate of absorption
The rate of Deuterium appearance in the blood during 60 minutes of rehydration
Time frame: during the first 60 minutes of rehydration
Rate of absorption
The rate of Deuterium appearance in the blood during 120 minutes of rehydration
Time frame: during the first 120 minutes of rehydration
Rate of absorption
The rate of Deuterium appearance in the blood during 180 minutes of rehydration
Time frame: during the first 180 minutes of rehydration
Rate of absorption
The rate of Deuterium appearance in the blood during 240 minutes of rehydration
Time frame: during the first 240 minutes of rehydration
Cumulative urine output
Total amount of urine output during rehydration
Time frame: during the first 3 hours of rehydration
Cumulative urine output
Total amount of urine output during rehydration
Time frame: during the first 4 hours of rehydration
Plasma copeptin
Plasam Copeptin during rehydration
Time frame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
Plasma volume
percent of plasma volume recovery during the rehydration
Time frame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
Free water Clearance
Free water clearance calculated based on plasma and urine osmolality
Time frame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
Free Osmotic Clearance
Free Osmotic clearance calculated based on plasma and urine osmolality
Time frame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
Thirst
Thirst estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception
Time frame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
Stomach fullness
Stomach fullness estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception
Time frame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
Taste Likeness
Taste Likeness estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception
Time frame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
Plan to share: No
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This study is completed, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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