An observational study in Hematopoietic and Lymphatic System Neoplasm and Malignant Solid Neoplasm, sponsored by Mayo Clinic. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-24.
Sponsored by Mayo Clinic · Observational
This study evaluates if three dimensional (3D) surface images can be used instead of the standard computed tomography (CT) scans for treatment planning in electron radiation therapy. 3D scanning has previously been used by several groups to design patient-specific devices to be 3D printed, and as has shown excellent agreement with CT obtained surfaces. Using 3D surface imaging instead of x-ray based CT, benefits include: no ionizing radiation used to produce images, shorter time between patient consultation and treatment, and ability to produce and evaluate patient-specific devices for electron therapy earlier in the treatment planning process. This study may help researchers learn how 3D surface scanning may be used to produce a virtual CT image of patient surfaces, and accurately replace traditional planning CT for treatment planning of electron based radiation therapy.
PRIMARY OBJECTIVES:
I. Develop and benchmark the necessary software to convert a 3D scan to a virtual CT.
II. Compare the spatial accuracy of virtual CTs from 3D scans to the planning CT.
III. Compare radiation treatment plans based on the virtual CTs from aim 2 to treatment plans based on the actual planning CTs.
OUTLINE: This is an observational study.
Patients undergo 3D surface scans on study. Patient's medical records are also reviewed on study.
Mayo Clinic is the lead sponsor of 3,218 studies on the registry; 670 are open to participants now.
Of its 445 completed or terminated interventional studies of FDA-regulated products, 313 (70%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patients being treated with electron radiation therapy at Mayo Clinic.
Exclusion Criteria:
Patients undergo 3D surface scans on study. Patient's medical records are also reviewed on study.
Other: Electronic Health Record Review · Procedure: Three-Dimensional Imaging
Medical records reviewed
Undergo 3D surface scans
Also known as: 3-D Imaging, 3-Dimensional Imaging, 3D Imaging, Medical Imaging, Three Dimensional
Dose distribution agreement between virtual and planning computed tomography (CT) datasets
The various three dimensional (3D) scans and CTs of the phantoms will be qualitatively assessed for agreement and accuracy to determine best practice, but there will be no statistical significance tested for. Will be conducted entirely on inanimate, plastic, anthropomorphic models (phantoms).
Time frame: Up to 2 months
Geometric agreement between virtual and planning CT datasets
Will test for distance to agreement differences between 3D scans taken at different time points (consultation, simulation, and treatment).
Time frame: Up to 2 months
Geometric agreement between 3D scans taken at different time points
Various dose metrics will be extracted from each of the three types of dose distribution: the ground truth CT based dose distribution, the 3D scan based virtual CT dose distributions, and the flat water phantom based dose distributions. Paired statistical tests will be used for each metric to test for significant differences between the various methods used to calculate the dose distributions.
Time frame: Up to 2 months
This study is completed, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Mayo Clinic