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Not yet recruitingNCT06394427Updated May 1, 2024

Neoadjuvant Chemoimmunotherapy in Stage IIIA- N2IIIB Non-small Cell Lung Cancer

An observational study in Non-small Cell Lung Cancer Stage ⅢA and Non-small Cell Lung Cancer Stage IIIB, sponsored by West China Hospital. Not yet recruiting. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2024-05-01.

Sponsored by West China Hospital · Observational

From the registry’s dates

  • Primary completion was expected by Aug 2024, 2 years 2 months ago, but the record still lists the study as not yet recruiting.
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
250
Ages
18 Years to 80 Years
Sex
All
01

Study summary

to explore the impact of preoperative neoadjuvant immunotherapy on perioperative outcomes and long-term prognosis of locally advanced NSCLC in the real world

02

Conditions studied

  • Non-small Cell Lung Cancer Stage ⅢA
  • Non-small Cell Lung Cancer Stage IIIB
03

In context

Lung Neoplasms

7,243 studies on the registry are indexed under Lung Neoplasms; 1,557 are open to participants now.

This study's planned enrollment of 250 is above the median of 189 across 1,514 observational studies indexed under Lung Neoplasms.

Browse Lung Neoplasms studies →

Lead sponsor

West China Hospital is the lead sponsor of 484 studies on the registry; 241 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

locally advanced NSCLC meeting the above crateria

Inclusion criteria

  • Confirmed as primary lung cancer through cytology or histological examination;

    • ECOG score of 0 or 1; ③ 18 years old or above;

      • Received imaging examination, with a preliminary clinical staging of stage III;

        • Received genetic testing and tested negative for EGFR mutations, ALK or ROS-1 fusion; ⑥ Accepting preoperative neoadjuvant immunotherapy combined with chemotherapy; ⑦ Receive surgical treatment after completion of neoadjuvant therapy; ⑧ The postoperative specimens were sent to the pathology department of our hospital for pathological testing, and a complete pathological report is available.

Exclusion criteria

Exclusion Criteria:

  • Patients with combined small cell lung cancer; ② Patients with severe liver/kidney dysfunction, cardiovascular disease, or systemic immune disorders;

    • Accept other neoadjuvant treatments; ④ Patients participating in any clinical trial.
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
250 participants (estimated)
Patient registry
No

Groups and cohorts

  • chemoimmunotherapy group 1

    patients received different cycles of neoadjuvant chemoimmunotherapy

    Other: cycles of neoadjuvant therapy and duration of waiting for surgery

  • chemoimmunotherapy group 2

    the duration of before patients received surgery after neoadjuvant chemoimmunotherapy

    Other: cycles of neoadjuvant therapy and duration of waiting for surgery

Interventions

  • Othercycles of neoadjuvant therapy and duration of waiting for surgery

    We intended to explore the cycles of neoadjuvant therapy and duration of waiting for surgery on the perioperative outcomes and long-term prognosis of locally advanced NSCLC in the real world

06

What researchers measure

Primary outcomes

  1. major pathological remission

    proportion of patients with no more than 10% residual viable tumor cells; patients who showed no viable tumor in the lung primary setting but lymph nodes show viable metastatic carcinoma were also classified as MPR

    Time frame: one month

  2. pathological complete remission

    proportion of patients without residual viable tumor cell on evaluation of resected lung cancer specimens including all sampled regional lymph nodes

    Time frame: one month

  3. survival time

    time since diagnosed with NSCLC

    Time frame: 5 years

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: No — The datasets are available upon reasonable request.

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 1, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06394427
Lead sponsor
West China Hospital
Responsible party
Pengfei Li (Research Assistant, West China Hospital) — Principal investigator
First posted
May 1, 2024
Start date
May 2024 (estimated)
Primary completion
Aug 2024 (estimated)
Completion
Aug 2025 (estimated)
Last update
May 1, 2024

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.

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