An observational study in Allergic Fungal Rhinosinusitis, sponsored by Assiut University. Status unknown. Per ClinicalTrials.gov, last updated 2024-04-19.
Sponsored by Assiut University · Observational
This study aims to assess Sinonasal risk factors for occurrence of unilateral versus bilateral allergic fungal rhino sinusitis regarding::
Introduction Allergic fungal rhinosinusitis (AFRS) is a subtype of CRS with nasal polyposis (CRSwNP) that is characterized by eosinophilic mucin within expanded sinus cavities and immunoglobulin E (IgE)-mediated type 1 hypersensitivity to fungal elements. This noninvasive disease process typically affects immunocompetent, younger patients in geographic regions with warm temperatures and high humidity, which facilitate fungal proliferation.
AFRS has a worldwide distribution pattern with varying prevalence. AFRS is presented in variable rates in different climatic, socioeconomic, and geographic factors. The disease prevalence showed predilection toward climatic factors
Assiut University is the lead sponsor of 5,050 studies on the registry; 2,174 are open to participants now.
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Patients will be divided into two groups:
Group (A): including patients with unilateral allergic fungal rhinosinusitis. Group (B): including patients with bilateral allergic fungal rhinosinusitis. Then all patient will subjected to EFSS under general anathesia with wide sinusotomics where intraoperative collection of data will be done as the follow
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Denovo cases . any Age Any sex. Patients diagnosed with unilateral or bilateral allergic fungal rhino sinusitis, meeting classic Bent and Kuhn criteria for AFRS:(10).
Nasal polyposis. Fungi on staining. Eosinophilic mucin without fungal invasion into sinus tissue., Type I hypersensitivity to fungi. Characteristic radiologic findings with soft-tissue differential densities on computed tomographic (CT) scanning
Exclusion criteria:
Diagnosis of benign or malignant neoplasm of the sinonasal cavity. Prior radiation therapy to the head or neck. Significant prior facial trauma. Autoimmune disorder. Craniofacial anomaly. Fungus ball. Immunodeficiency. Cystic fibrosis. Patients unfit for surgery. Previous nasal surgery or recurrent cases .
functional endoscopic sinus surgery for diagnosis the disease
Sinonasal risk factors for occurrence of unilateral versus bilateral allergic fungal rhinosinusitis
analysis of the risk factors of unilateral versus bilateral allergic fungal rhinosinusitis
Time frame: baseline
No study locations are listed for this record.
Plan to share: No
Start is estimated for May 2024; primary completion for May 2025, 12 months later.
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This study is status unknown, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.
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Allergic Fungal Sinusitis