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RecruitingNCT06362837REACTS-INUpdated Apr 29, 2026

Evaluation of REACTS-IN, an Intervention to Improve Nutrition, Hygiene, and Sexual and Reproductive Health Services

An interventional study of Education intervention on nutrition, gender equity, WASH, sexual and reproductive health rights and school-based iron-folic acid supplement program in Stunting, Gender Equality and Acceptability of Health Care, sponsored by McGill University. Recruiting at 3 sites in 3 countries. Per ClinicalTrials.gov, last updated 2026-04-29.

Sponsored by McGill University · Not applicable, Interventional, and Other

From the registry’s dates

  • Started Sep 2024; still recruiting 2 years 2 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
13,500
Allocation
Non-randomized
Sex
All
01

Study summary

This is an independent evaluation of World VIsion's 7-year quasi-experimental intervention to improve nutrition, nutrition-related rights and gender equality for women, adolescent girls, and children under five years of age in rural Bangladesh, Kenya, and Tanzania. The evaluation will collect baseline, midline, and end-line data from intervention communities, schools, and health facilities. Only baseline and endline will be collected on the comparison communities. The evaluation objectives are to test if the intervention improved indicators for (i) child anthropometry, (ii) maternal and child dietary practices, (iii) women's empowerment, and (iv) equitable health service access for nutrition and sexual and reproductive needs. The evaluation analysis will take into account gender differences in the indicators.

Read the detailed description

This is an independent evaluation of World VIsion's 7-year quasi-experimental intervention ("Realizing Gender Equality, Attitudinal Change and Transformative Systems in Nutrition", REACTS-IN) to improve nutrition, nutrition-related rights and gender equality for women, adolescent girls, and children under five years of age in rural Bangladesh, Kenya, and Tanzania. REACTS-IN is a multi-sectoral approach, integrating nutrition-related determinants, such as water, sanitation, and hygiene (WASH) interventions and health systems strengthening, to improve access to quality and gender-responsive health systems with increased capacity to prevent and treat malnutrition, especially at the primary health care level. REACTS-IN includes both nutrition-specific (e.g., school-based iron-folic acid supplement program) and nutrition-sensitive (e.g., WASH education) activities delivered through local health systems and/or schools, and communities.

This independent evaluation will include three data collection at baseline, midpoint, and end-line to evaluate the performance indicators for the ultimate and intermediate outcomes. This includes indicators for child anthropometry, maternal and child dietary practices, women's empowerment, and equitable health service access for nutrition and sexual and reproductive needs. The evaluation analysis will take into account gender differences in the indicators.

The data collection will be carried out with intervention communities as well as with comparison communities. The estimated household sample is 463 households (women, husbands, child)/arm/country per time point, selected through a multi-stage cluster sampling methodology. The household baseline survey with a representative sample of mothers with children (0-5.9 mo; 6-23.9 mo; 24-59.9 mo) will be compared to the values at midpoint (to assess initial impact and the need for program adjustments) and at end-line (to assess the total impact of the project). The surveys will include sociodemographic, economic, and environmental information to assess the indicators for the local context. The evaluation also includes a sample of 500 school-going adolescents (250 boys, 250 girls)/arm/country per time point to assess indicators of knowledge about nutrition, menstrual hygiene management, and sexual and reproductive health. Finally, a sample of approximately 24 health staff and community leaders will provide qualitative data on gender-equitable access to services per arm/country for baseline and end-line.

Although the project also is working in Somalia, this independent evaluation does not include data collection in Somalia.

02

Conditions studied

  • Stunting
  • Gender Equality
  • Acceptability of Health Care
  • Diet; Deficiency
  • Empowerment

Keywords

  • nutrition
  • gender equity
  • health services
  • sexual and reproductive rights
  • dietary diversity
  • anthropometry
  • sexual and reproductive health services
  • WASH
03

In context

Growth Disorders

227 studies on the registry are indexed under Growth Disorders; 25 are open to participants now.

This study's planned enrollment of 13,500 is above the median of 413 across 143 interventional studies indexed under Growth Disorders.

Browse Growth Disorders studies →

Lead sponsor

McGill University is the lead sponsor of 249 studies on the registry; 51 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

(i)Women:

  • 15-49 y of age
  • biological mother of child in the home who is 0-5.9, 6-23.9, or 24-59.9 months
  • has lived in the community for at 12 months

(ii) Husbands/partners:

  • no age limit
  • lives in the home with index woman
  • has lived in community for at least 12 months

(iii) Adolescents:

  • 10-19 years
  • male or female
  • has been in target school for at least 6 months
  • lives in the target community

(iv) Children:

  • 0-5.9, 6-23.9, or 24-59.9 months

Exclusion criteria

Exclusion Criteria:

(i) Children:

  • no limitation on normal diet or growth (birth defects, illnesses)
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
13,500 participants (estimated)

Study arms

  • Experimental
    Intervention

    Includes multiple activities, depending on country, including support of school-based iron-folic acid supplementation program; promotion of bio-fortified crops (sweet potatoes, beans, rice, corn); training on nutrition, water \& sanitation, gender equity for rural communities through community groups and for health facility staff; support to improve gender-sensitive health services for nutrition, sexual and reproductive health,

    Behavioral: Education intervention on nutrition, gender equity, WASH, sexual and reproductive health rights · Dietary Supplement: school-based iron-folic acid supplement program · Behavioral: Health service training on equitable access to nutrition, health, and sexual and reproductive services · Dietary Supplement: bio-fortified crops

  • No intervention
    Comparison

    No intervention will take place. Standard of care will be available in the health facilities and schools.

Interventions

  • BehavioralEducation intervention on nutrition, gender equity, WASH, sexual and reproductive health rights

    Educational training on nutrition, gender equity, WASH, sexual and reproductive health rights will take place in communities (including schools) for women, men, and adolescents

  • Dietary supplementschool-based iron-folic acid supplement program

    The program will help support and promote the school-based programs of weekly iron and folic acid supplementation for adolescent girls, in countries where it is allowed.

  • BehavioralHealth service training on equitable access to nutrition, health, and sexual and reproductive services

    Training and support activities to make gender-equitable nutrition, health, and sexual and reproductive services in the health facilities

  • Dietary supplementbio-fortified crops

    The program promotes and distributes bio-fortified crops, including orange-fleshed sweet potatoes, rice, beans, and corn

06

What researchers measure

Primary outcomes

  1. Gender equality

    Percent of households with children \< 59.9 mo that have achieved gender equality

    Time frame: Change between baseline and study completion, an average of 5 years

  2. Child anthropometry

    Percent of children 6-59 mo of age who are stunted

    Time frame: Change between baseline and study completion, an average of 5 years

Secondary outcomes

  1. Antenatal care

    Percent of mothers of children 0-6 months who attended at least four ante-natal visits during the last pregnancy from skilled health personnel

    Time frame: Change between baseline and study completion, an average of 5 years

  2. Contraception use by women and partners

    Percent of women aged 15-49 years married or in union, who are currently using, or whose sexual partner is using at least one modern contraception method

    Time frame: Change between baseline and study completion, an average of 5 years

  3. Child diet

    Percent of children 6-23.9 months of age, who receive minimum dietary diversity and minimum meal frequency

    Time frame: Change between baseline and study completion, an average of 5 years

  4. Sexual and reproductive health services for adolescents

    Percent of adolescent girls (10-19) who report that they were offered sexual and reproductive health services

    Time frame: Change between baseline and study completion, an average of 5 years

  5. Gender equitable health services for nutrition, health, and sexual and reproductive health

    Percent of health facilities promoting gender equitable and responsive nutrition, health, and sexual and reproductive services

    Time frame: Change between baseline and study completion, an average of 5 years

  6. Exclusive breastfeeding

    Percent of children 0-5.9 mo who are exclusively breastfed

    Time frame: Change between baseline and study completion, an average of 5 years

  7. Use of family planning

    Percent of women 15-49 y who decided to use family planning

    Time frame: Change between baseline and study completion, an average of 5 years

  8. adolescent knowledge of nutrition, menstrual hygiene, and sexual and reproductive health

    Percent of adolescent girls and boys with appropriate knowledge about nutrition, menstrual hygiene, and sexual and reproductive health

    Time frame: Change between baseline and study completion, an average of 5 years

  9. maternal knowledge on nutrition

    Percent of women 15-49 y with appropriate knowledge on good maternal nutrition

    Time frame: Change between baseline and study completion, an average of 5 years

  10. Attended birth deliveries

    Percent of deliveries attended by skilled birth personnel

    Time frame: Change between baseline and study completion, an average of 5 years

  11. maternal knowledge of family planning

    Percent of mothers who know at least 3 modern methods of family planning

    Time frame: Change between baseline and study completion, an average of 5 years

  12. maternal knowledge of exclusive breastfeeding

    Percent of mothers who know at least 3 benefits of exclusive breastfeeding

    Time frame: Change between baseline and study completion, an average of 5 years

  13. mothers planting biofortified crops

    Percent of mothers who have planted biofortified crops from REACTS-IN materials

    Time frame: Change between baseline and study completion, an average of 5 years

  14. mothers planting nutrient dense local vegetables

    Percent of mothers who have planted nutrient dense local vegetables from REACTS-IN seeds

    Time frame: Change between baseline and study completion, an average of 5 years

  15. mothers planting trees

    Percent of mothers who have planted fruit tress from REACTS-IN materials

    Time frame: Change between baseline and study completion, an average of 5 years

  16. hygenic toilets

    Percent of households with hygienic toilets

    Time frame: Change between baseline and study completion, an average of 5 years

  17. community health worker visit

    Percent of households that received at least one community health worker visit in last month

    Time frame: Change between baseline and study completion, an average of 5 years

  18. Adolescent iron folic acid supplements

    Percent of adolescent girls who received the recommended scheme of weekly iron-folic actic supplements

    Time frame: Change between baseline and study completion, an average of 5 years

  19. health facility

    Percent of health facilities scoring \> 80 on planning assessment

    Time frame: Change between baseline and study completion, an average of 5 years

07

Study locations

2 of 3 sites recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 29, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06362837
Lead sponsor
McGill University
Collaborators
World Vision Canada, Global Affairs Canada
Responsible party
Grace S. Marquis (Associate Professor, McGill University) — Principal investigator
First posted
Apr 12, 2024
Start date
Sep 1, 2024
Primary completion
Jun 30, 2029 (estimated)
Completion
Dec 31, 2029 (estimated)
Last update
Apr 29, 2026

Study contacts

Grace S Marquis, PhD
Contact
grace.marquis@mcgill.ca
1-514-398-7839
Aishat Abdu, PhD
Contact
aishat.abdu@mail.mcgill.ca
Grace S Marquis, PhD
principal investigator · McGill University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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