An interventional study of De Pie Intervention and Active Comparison Group: Healthy Actions And Lifestyles To Avoid Dementia (HALT-AD) in Sedentary Behavior, Physical Inactivity and Alzheimer Disease, Protection Against, sponsored by Kaiser Permanente. Active, not recruiting at 2 sites in United States. Open to participants aged 55 Years to 89 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-21.
Sponsored by Kaiser Permanente · Not applicable, Interventional, and Prevention
In this randomized controlled trial, study staff will randomize 130 Hispanic/Latino adults without dementia and over age 55 from Southern California and from Kaiser Permanente Washington (State) to either the culturally adapted De Pie physical activity intervention or an active comparison program focusing on general brain health topics. The purpose of this study is to determine if 12 weeks of the culturally adapted and fully remote De Pie y a Movernos intervention improves self-efficacy, habit strength, social support, and enjoyment for physical activity (PA), thus promoting adherence to moderate-intensity physical activity (MIPA) guidelines (150 minutes/week).
Building on the cultural adaptation of our preliminary R61 De Pie pilot study, study staff will randomize 130 Hispanic/Latino adults without dementia and over age 55 from Southern California and from Kaiser Permanente Washington to either the culturally adapted De Pie physical activity intervention or an active comparison program, Healthy Actions and Lifestyles to Avoid Dementia (HALT-AD), focusing on general brain health topics. The investigators will determine if De Pie improves physical activity (Aim 1) and psychosocial mediators (self-efficacy, habit strength, social support, and enjoyment for physical activity, [PA]), thus promoting adherence to moderate-intensity physical activity (MIPA) guidelines (150 minutes/week; Aim 2). The intervention period lasts 12 weeks.
The investigators target middle-aged and older Hispanic/Latino adults that are under-studied and have a higher risk of Alzheimer's disease and related dementias (ADRD), compared to non-Hispanic White older adults. Study staff employ a community engaged and collaborative approach to culturally adaptive the intervention framework and a staircase intervention approach designed to build self-efficacy, PA habit strength, social support, and PA enjoyment. Results will inform culturally adapted, theory-based approaches to prevent ADRD in the Hispanic/Latino community.
332 studies on the registry are indexed under Sedentary Behavior; 155 are open to participants now.
This study's planned enrollment of 130 is above the median of 70 across 287 interventional studies indexed under Sedentary Behavior.
Browse Sedentary Behavior studies →Kaiser Permanente is the lead sponsor of 385 studies on the registry; 41 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 3 (50%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion criteria are as follows:
The De Pie intervention program receives a sedentary behavior reduction and physical activity promotion intervention centered on two steps: Step 1) reduce sitting time and move more throughout the day; Step 2) if cleared by a safety assessment and blood pressure check, participants can work towards adding structured bouts of exercise into their day.
Behavioral: De Pie Intervention
Those randomized to HALT-AD (Healthy Actions and Lifestyles to Avoid Dementia) will receive one phone call to introduce them to preventing cognitive decline through various lifestyle behaviors (e.g. stress reduction, healthy diet, healthy sleep) other than physical activity. They will be encouraged by the Health Coach upon randomization to complete one module approximately every week (there are 10 modules in total).
Other: Active Comparison Group: Healthy Actions And Lifestyles To Avoid Dementia (HALT-AD)
Participants are guided by a health coach trained in motivational interviewing through 6 biweekly phone sessions. Each session involves reviewing goals and problem-solving barriers from the prior 2 weeks experience; covering a topic related to Step 1 goals (or Step 2 goals if they pass the safety assessment) such as how to enjoy movement, social support, and using your surroundings; and setting goals and an action plan for the following two weeks.
Those in the active comparison program will receive no additional health coaching sessions. They will work through the HALT-AD content at their own pace, setting goals in the online platform as they go.
Change in Moderate Intensity Physical Activity (MIPA) minutes/day
Time (minutes) spent being physically active during waking hours will be measured objectively by the ActiGraph worn for one week at Baseline and again after 12 weeks
Time frame: Baseline to 12 weeks
Meet MIPA guidelines of 150 minutes physical activity per week
Time (minutes) spent being physical active during waking hours will be measured objectively by the ActiGraph worn for one week at Baseline and again after 12 weeks
Time frame: Baseline to 12 weeks
Average daily sedentary time
mins/day; ≤18 counts per 15s will be measured objectively by the ActiGraph worn for one week at baseline and again after 12 weeks.
Time frame: Baseline to 12 weeks
Average daily light intensity physical activity (LPA)
mins/day; 19-518 counts per 15s will be measured objectively by the ActiGraph worn for one week at Baseline and again after 12 weeks
Time frame: Baseline to 12 weeks
Average steps/day
Change in daily steps will be measured objectively by the ActiGraph worn for one week at Baseline and again after 12 weeks
Time frame: Baseline to 12 weeks
This study is active, not recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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