An observational study in Infections, Transplant Complication and Transplant Failure, sponsored by Technical University of Munich. Recruiting at 1 site in Germany. Per ClinicalTrials.gov, last updated 2024-04-23.
Sponsored by Technical University of Munich · Observational
Medical data and biological samples obtained from transplant patients are collected and managed across Germany with the help of the DZIF Transplant Cohort. The data and samples form the basis of scientific studies which investigate the connections between numerous factors influencing an organ's susceptibility to infection and organ function.
Infections in transplant recipients have a decisive impact on graft function and survival of the transplant recipient, but many issues are still poorly understood. For example, little is known about the long-term consequences of many infections on graft survival/function and graft- versus-host disease (GvHD), the role of individual susceptibility to bacterial, viral and fungal colonisation under immune suppression, the evolution of the antiviral T cell repertoire, the long- term impact of antiviral therapy on graft and patient survival or changes in the physiological microbiome that may have a bearing on colonisation with pathogenic microbes. Taking advantage of the fact that most of the university hospitals with sizeable transplantation programs in Germany are also DZIF partners, we will establish a large multicentre prospective observational cohort of transplant recipients.
6,688 studies on the registry are indexed under Infections; 807 are open to participants now.
This study's planned enrollment of 3,000 is above the median of 240 across 2,136 observational studies indexed under Infections.
Browse Infections studies →Technical University of Munich is the lead sponsor of 315 studies on the registry; 55 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients of any age who have received a kidney, pancreas, liver, heart or stem cell transplant at one of the listed partner centres
Exclusion Criteria:
Realisation of studies that focus on the the medical needs of transplant patients, particularly with regard to their susceptibility to infection
Provision of collected data and biosamples to research groups for the realisation of scientific studies with a number of resources that individual clinics could not provide on their own
Time frame: 10 years
Plan to share: Yes — The use of collected data and biosamples is possible on the basis of an application to the Scientific Steering Committee of the transplant cohort. Cooperations with members of the cohort are welcome
Supporting information: Study protocol, Icf
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Technical University of Munich