An observational study in Obesity, sponsored by Istituto Auxologico Italiano. Recruiting at 2 sites in Italy. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2025-08-03.
Sponsored by Istituto Auxologico Italiano · Observational
Overweight and obesity are increasingly prevalent worldwide. Weight excess increases the risk of in developing the metabolic syndrome, which is composed by a set of cardiometabolic risk factors such as abdominal adiposity, dyslipidemia, high blood pressure and elevated fasting glucose levels. Obesity and the metabolic syndrome are known to be risk factors for the development of chronic kidney disease. It is not clear however, whether they can be considered independent risk factors for impaired renal function and renal damage. Whereas obesity may represent an independent risk factor for renal damage, it is not clear yet if the contemporaneous presence of obesity and metabolic alterations is associated with an additional increase in the risk.
It may be important to understand the relationship between obesity, metabolic syndrome and renal health, as treatment strategies may be different for the two metabolic phenotypes of obesity, i.e., metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) patients.
The primary objective of this multicentre observational prospective study is to assess the relationship between metabolic phenotype and reduced renal function (glomerular filtration rate \<90 ml/min/1.73m2 or microalbuminuria 30-300 mg/24h) in a population of 1000 patients with overweight or obesity.
The secondary aim is to study the association between diet quality, consumption of ultra-processed foods and indicators of reduced renal function and renal damage.
6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.
This study's planned enrollment of 1,000 is above the median of 135 across 1,283 observational studies indexed under Obesity.
Browse Obesity studies →Istituto Auxologico Italiano is the lead sponsor of 196 studies on the registry; 78 are open to participants now.
Counted across the registry records on this site, refreshed daily.
1000 patients with weight excess or overweight (BMI > 25 kg/m2)
Exclusion Criteria:
Other: Diet
Pesonalized diet plan, devoloped according to Guidelines for dietary treatment of obesity, to be followed for a duration of 12 months
Glomerular filtration rate
Change in glomerular filtration after dietary intervention of 12 months
Time frame: At baseline and after 12 months of dietary intervention programme
Microalbuminuria
Change in microalbuminuria after dietary intervention of 12 months
Time frame: At baseline and after 12 months of dietary intervention programme
Glycemia
Change in glycemia after dietary intervention of 12 months
Time frame: At baseline and after 12 months of dietary intervention programme
Body mass index
Change in body mass index after dietary intervention of 12 months
Time frame: At baseline and after 12 months of dietary intervention programme
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Istituto Auxologico Italiano