A Phase 2/3 interventional study of Traditional scorpion antivenom regimen and Serial dose of scorpion antivenom regimen in Centruroides Envenomation, sponsored by Selene Guadalupe Huerta Olvera. Completed at 1 site in Mexico. Open to participants aged 18 Years to 99 Years. Per ClinicalTrials.gov, last updated 2025-12-17.
Sponsored by Selene Guadalupe Huerta Olvera · Phase 2/3, Interventional, and Treatment
The clinical study aims to compare the effectiveness of applying two different regimens of scorpion antivenom therapy. In the first regimen (control), the medication is administered to all patients, and depending on the severity of the condition, the dosage varies. In the experimental regimen, an identical dose of scorpion antivenom is administered to patients exhibiting signs and symptoms of scorpion sting intoxication, in addition to pain and other symptoms at the sting site. The primary response variable is the time taken for signs and symptoms to resolve, but differences in complications, adverse effects, venom and antivenom concentration in the blood, and the need for other therapeutic measures are also evaluated.
This is the only study on the registry with Selene Guadalupe Huerta Olvera as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Active/placebo comparator
Drug: Traditional scorpion antivenom regimen
Drug: Serial dose of scorpion antivenom regimen
All patients will be classified according to two severity scales. The pharmacist, who is the only team member aware of which group each patient was assigned to, will consider the classification corresponding to the classification proposed by the Mexican Clinical Practice Guideline to decide the dose of scorpion antivenom. Scorpion antivenom will be administered to all patients. Patients in this group will receive between one and three vials every 30 minutes, depending on the severity of the condition (one vial for patients classified as grade I, two vials for patients classified as grade II, and three vials for patients classified as grade III)
All patients will be classified according to two severity scales. The pharmacist, who is the only team member aware of which group each patient was assigned to, will consider the classification corresponding to the American classification to decide the dose of scorpion antivenom. Scorpion antivenom will be administered only in the presence of signs and/or systemic symptoms of intoxication, excluding signs and symptoms at the sting site. Patients in this group will receive between one and two vials every 30 minutes, depending on the severity of the condition (one vial for patients classified as grade III and two vials for patients classified as grade IV)
Time to resolution of signs and symptoms
Time to resolution of signs and symptoms from admission and from the estimated time of the sting
Time frame: two and a half to five hours
Serum venom concentration
Serum venom concentration upon patient arrival, after administration of antivenom, and upon reporting the absence of signs of intoxication
Time frame: two and a half to five hours
Mortality
Mortality rate of each group
Time frame: two and a half to five hours
Length of intrahospital stay
Time from patient admission to discharge due to patient improvement
Time frame: two and a half to five hours
Serum antivenom concentration
Scorpion antivenom concentration at five minutes after administration, prior to secondary doses, and prior to discharge
Time frame: two and a half to five hours
Plan to share: No
This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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Scorpion Stings