An interventional study of site preservation in Periodontal Pocket, Periodontal Bone Loss and Impacted Third Molar Tooth, sponsored by The Dental Hospital of Zhejiang University School of Medicine. Recruiting at 1 site in China. Open to participants aged 26 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-03-19.
Sponsored by The Dental Hospital of Zhejiang University School of Medicine · Not applicable, Interventional, and Treatment
To evaluate the clinical effect of site preservation after third molars extraction by using tooth extraction of third molars with site preservation using bio-oss and bio-guide in preventing the formation of deep periodontal pockets in the distal of second molars.
The mandibular third molar is the last tooth to erupt in the dentition, and due to the insufficient eruption position, it can lead to different degrees of impact. During the eruption of impacted tooth, the crown may be partially or completely covered by the gingival flap. A deep blind pocket is formed between the gingival flap and the tooth crown, and food and bacteria are easily impinged in the blind pocket. Under the influence of oral environment and dental plaque, the presence of blind pockets can lead to the loss of periodontal attachment and the absorption of alveolar bone, thus affecting the distal periodontal status of adjacent molars.
Organic bone xenograft material composed of absorbable organic bovine hydroxyapatite is one of the commonly used transplantation materials for repairing bone defects. The application effect of allogeneic bone materials in periodontal therapy has been recognized by many experts and scholars. Guided bone regeneration (GBR), as a conventional periodontal bone graft, has achieved good results in periodontal tissue regeneration. Aljuboori et al. found that when the third molar was removed and GBR was performed at the same time, the depth of distal periodontal pocket probing of the adjacent second molar was significantly reduced in the re-examination 6 months after surgery.
Hence, this study intends to use xenograft combined with barrier membrane to improve the formation of distal periodontal pocket of the second molars after third molars extraction.
297 studies on the registry are indexed under Alveolar Bone Loss; 76 are open to participants now.
This study's planned enrollment of 30 is above the median of 25 across 254 interventional studies indexed under Alveolar Bone Loss.
Browse Alveolar Bone Loss studies →The Dental Hospital of Zhejiang University School of Medicine is the lead sponsor of 25 studies on the registry; 16 are open to participants now.
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Exclusion Criteria:
Tooth extraction of third molars
Procedure: site preservation
Tooth extraction of third molars with site preservation using bio-oss (0.5g, Small granule) and bio-guide (25\*25mm size). The bone graft material used in the surgical procedure was provided by Geistlich Pharma AG.
Procedure: site preservation
Tooth extraction of third molars with site preservation using bio-oss (0.5g, Small granule) and bio-guide (25\*25mm size). The bone graft material used in the surgical procedure was provided by Geistlich Pharma AG.
Probing pocket depths (PPD)
The depth of the periodontal pocket is examined with a periodontal probe. Probing pocket depths (PPD) measured in millimeters at six sites: disto-vestibular (DV), centro-vestibular (CV), mesio-vestibular (MV), disto-lingual (DL), centro-lingual(CL), mesio-lingual (ML) in postoperative 14days, 3, 6 and 12 months. The distal measurements are the primary outcomes. The higher the value, the worse the periodontal condition.
Time frame: postoperative 14 days, 3 6 and 12 months
Distal bone wall defect (DBWD)
The height of distal bone wall defect of the second mandibular molar is measured by cone-beam CT.
Time frame: postoperative 14 days, 3 6 and 12 months
Clinical attachment lose (CAL)
clinical attachment lose (CAL) were measured in millimeters at six sites: disto-vestibular (DV), centro-vestibular (CV), mesio-vestibular (MV), disto-lingual (DL), centro-lingual(CL), mesio-lingual (ML). The distal measurements are the primary outcomes.
Time frame: postoperative 14 days, 3 6 and 12 months
Bleeding on probing (BOP)
Periodontal probing for bleeding can determine whether the gingiva is in a state of inflammation or whether periodontal disease is in an active phase.
Time frame: postoperative 14 days, 3 6 and 12 months
Pain score
Visual Analog Score for pain
Time frame: pre-operation, postoperative 14 days, 3 6 and 12 months
Patient satisfaction
Physicians Global Assessment to measure quality of life
Time frame: pre-operation, postoperative 14 days, 3 6 and 12 months
Gingival index (GI)
The higher the index, the worse the periodontal condition.
Time frame: pre-operation, postoperative 14 days, 3 6 and 12 months
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The Dental Hospital of Zhejiang University School of Medicine