An observational study in General Anesthetics Toxicity, sponsored by Peking Union Medical College Hospital. Recruiting at 1 site in China. Open to participants aged 6 Years to 16 Years. Per ClinicalTrials.gov, last updated 2025-11-18.
Sponsored by Peking Union Medical College Hospital · Observational
In the past, a large number of animal studies have suggested that anesthesia exposure has potential neurotoxic effects, resulting in persistent cognitive and behavioral deficits. At present, there is still a lack of sufficient clinical research evidence to prove whether anesthesia exposure has long-term effects on neurodevelopment. The existing clinical research data suggests that a single short-time anesthesia exposure in young children does not affect long-term neurodevelopmental outcomes. Early onset scoliosis, including congenital scoliosis, is a type of scoliosis deformity that occurs before the age of 10. Posterior scoliosis correction surgery is one of the common treatment. There is currently no research indicating the impact of early single or multiple long-duration anesthesia exposure on the neurological development of children with congenital scoliosis. The aim of this study is to determine the long-term effect of general anesthesia exposure on neurocognitive function and behavior in children with congenital scoliosis, in order to provide reference for related clinical work.
Peking Union Medical College Hospital is the lead sponsor of 1,115 studies on the registry; 463 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Children diagnosed with congenital scoliosis
Exclusion Criteria:
Children unexposed to general anesthesia before school age (\<=6y)
Children singly exposed to general anesthesia before school age (\<=6y)
Procedure: General anesthesia
Children multiply exposed to general anesthesia before school age (\<=6y)
Procedure: General anesthesia
General anesthesia including inhaled and intravenous
full-scale intelligence quotient, FSIQ
Measured by Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV)
Time frame: At the time of collecting baseline demographic data
Verbal Comprehension Index (VCI), Perceptual Reasoning/Organization Index (PRI/POI)
Measured by Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV)
Time frame: At the time of collecting baseline demographic data
CBCL Total score, CBCL Internalizing score, CBCL Externalizing score
Measured by Child Behavior Checklist (CBCL)
Time frame: Within six months of WISC-IV assessment
SDQ total difficulties score, SDQ internalizing problems score, SDQ externalizing problems score, SDQ prosocial behavior score
Measured by Strengths and Difficulties Questionnaire (SDQ)
Time frame: Within six months of WISC-IV assessment
Plan to share: Yes — IPD that underlie results in a publication
Supporting information: Study protocol, Sap, Icf, Csr
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Peking Union Medical College Hospital