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RecruitingNCT06293196Updated Jan 21, 2026

Effects of Acupoint Massage Around Eyes on Ocular Biological Indexes

An interventional study of acupressure in Investigating the Effects of Periocular Acupressure on Ocular Biological Indicators, sponsored by Zhongnan Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-21.

Sponsored by Zhongnan Hospital · Not applicable, Interventional, and Other

From the registry’s dates

  • Primary completion was expected by Jun 2026, 3 months ago, but the record still lists the study as recruiting.
  • Registered 5 months after the study started (first participant enrolled Sep 2023, registered Feb 2024).
  • Started Sep 2023; still recruiting 3 years 1 month later.
Phase
Not applicable
Study type
Interventional
Enrollment
55
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

This study aims to investigate whether the acupoint eye exercise could impact the biological parameters of the eye.

02

Conditions studied

  • Investigating the Effects of Periocular Acupressure on Ocular Biological Indicators
03

In context

Lead sponsor

Zhongnan Hospital is the lead sponsor of 103 studies on the registry; 48 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • healthy people of all ages

Exclusion criteria

Exclusion Criteria:

  • presence of systemic diseases
  • history of other eye diseases, surgeries, and/or medications, as well as eye trauma
  • incomplete healing of the surgical site after eye surgery
  • consumption of coffee, tea, or vasodilators within 6 hours before the commencement of the test
  • exclusion of children, pregnant, and lactating women
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
55 participants (estimated)

Study arms

  • Experimental
    standard Chinese acupoint eye exercise group

    The volunteers performed a set of standard Chinese acupoint eye health exercises.

    Other: acupressure

  • Experimental
    fake acupoint eye exercise group

    Volunteers performed a group of fake acupoint eye health exercises, the acupoint design in the place without acupoints.

    Other: acupressure

  • No intervention
    simple eye closure group

    The volunteers only closed their eyes and did not perform acupressure.

  • No intervention
    simple distance observation group

    The volunteers only looked far without acupressure.

Interventions

  • Otheracupressure

    Massage acupoints and non-acupoint areas around the eyes.

06

What researchers measure

Primary outcomes

  1. The effect of ocular acupoint massage on ocular blood flow.

    Ocular blood flow indicators were obtained using Optical Coherence Tomography (OCT).

    Time frame: Ocular blood flow indicators were measured once at pre-intervention, immediately post-intervention, and at 10, 20, and 30 minutes post-intervention.

  2. The effect of ocular acupoint massage on intraocular pressure.

    Intraocular pressure (IOP) of patients was measured and recorded with the ICARE rebound tonometer.

    Time frame: Intraocular pressure was measured once before the intervention and once immediately after the intervention.

  3. The effect of ocular acupoint massage on the diameter of Schlemm's canal.

    Imaging of the nasal and temporal corneoscleral regions of the right eye was performed using swept-source anterior segment optical coherence tomography (SS-AS-OCT). The diameter of Schlemm's canal was measured manually.

    Time frame: Anterior segment imaging was performed once before and once immediately after the intervention to obtain the diameter values of Schlemm's canal.

  4. The effect of ocular acupoint massage on the area of Schlemm's canal.

    Imaging of the nasal and temporal corneoscleral regions of the right eye was performed using swept-source anterior segment optical coherence tomography (SS-AS-OCT). The area of Schlemm's canal was measured manually.

    Time frame: Anterior segment imaging was performed once before and once immediately after the intervention to obtain the area values of Schlemm's canal.

  5. The effect of ocular acupoint massage on the width of the trabecular meshwork.

    Imaging of the nasal and temporal corneoscleral regions of the right eye was performed using swept-source anterior segment optical coherence tomography (SS-AS-OCT). The width of the trabecular meshwork was measured manually.

    Time frame: Anterior segment imaging was performed once before and once immediately after the intervention to obtain the width values of the trabecular meshwork.

  6. The effect of ocular acupoint massage on the thickness of the trabecular meshwork.

    Imaging of the nasal and temporal corneoscleral regions of the right eye was performed using swept-source anterior segment optical coherence tomography (SS-AS-OCT). The thickness of the trabecular meshwork was measured manually.

    Time frame: Anterior segment imaging was performed once before and once immediately after the intervention to obtain the thickness values of the trabecular meshwork.

  7. The effect of ocular acupoint massage on the tear film.

    The Keratograph was used to dynamically monitor the tear film break-up location and break-up time in a non-contact manner before and after the intervention, with tear meniscus height measured manually.

    Time frame: The Keratograph was performed once before the intervention and once immediately after the intervention.

Secondary outcomes

  1. The effect of ocular acupoint massage on blood pressure.

    Blood pressure was measured using the cuff pressurization method.

    Time frame: Blood pressure was measured once before the intervention and once immediately after it.

  2. The effect of ocular acupoint massage on heart rate.

    Heart rate was monitored using the cuff occlusion method.

    Time frame: Heart rate was measured once before the intervention and once immediately after it.

07

Study locations

1 of 1 sites recruiting
  • Zhongnan Hospital of Wuhan University
    Wuhan, Hubei 430000, China
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 21, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06293196
Lead sponsor
Zhongnan Hospital
Responsible party
Sponsor
First posted
Mar 5, 2024
Start date
Sep 1, 2023
Primary completion
Jun 30, 2026 (estimated)
Completion
Jun 30, 2026 (estimated)
Last update
Jan 21, 2026

Study contacts

Min Ke, doctor of medicine
Contact
Keminyk@163.com
18672395959

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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