An interventional study of low intensity pulsed ultrasound and iPRF in Effect of Platelet Rich Fibrin Versus Low Intensity Pulsed Ultrasound During Clear Aligner Therapy, sponsored by Al-Azhar University. Enrolling by invitation at 1 site in Egypt. Open to participants aged 15 Years to 22 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-02-26.
Sponsored by Al-Azhar University · Not applicable, Interventional, and Basic science
The aim of this prospective clinical project will be to compare the effect of platelet rich fibrin versus low- intensity pulsed ultrasound on therate of different orthodontic tooth movements during clear aligner therapy.
The aim of this prospective clinical project will be to compare the effect of platelet rich fibrin versus low- intensity pulsed ultrasound on therate of different orthodontic tooth movements during clear aligner therapy.specifically canine retraction,incsiors levellingand aliggnment,maxillary molar distalizationand incisors intrusion
Al-Azhar University is the lead sponsor of 505 studies on the registry; 167 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria:
Lower incisor leveling and alignment Inclusion criteria Complete permanent dentition (third molars not included); Moderate mandibular anterior crowding (with little's irregularity index score greater than 4 mm) who required non-extraction approach in the mandibular arch; No tooth size, shape or root abnormalities visible on the patient's radiographic records; No spaces in the mandibular arch; No blocked out tooth that did not allow for placement of the bracket at the
initial bonding appointment; 6. No required management with interproximal stripping, inter-maxillary elastics, open NiTi springs, and removable or extra-oral devices. Canine retraction Eligibility criteria
Age, 15 to 25 years; Class ii division 1 malocclusion with mild or no crowding; No previous orthodontic treatment; No systemic disease that might have affected bone formation or density, such as osteoporosis, hyperparathyroidism, or vitamin d deficiency; Adequate oral hygiene; Probing depth values not exceeding 3 mm across the Entire dentition; Adequate thickness of the attached gingiva (1-2 mm); No radiographic evidence of bone loss -
Exclusion Criteria:Patients who required surgery to correct skeletal discrepancies. Patients with congenital dentoskeletal disorders. Missed or mutilated teeth in maxillary arch. Patients with poor oral hygiene and/or periodontally compromised patients Severe dental crowding that necessitates an extraction approach 2. Abnormal anteroposterior and vertical relationships; 3. Patients with cleft lip and palate, anomalies, and syndromes; 4. Previous orthodontic 5. Treatment; 6. Regular medications intake that could interfere with otm. -
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application of LIPUS with translation of closure of premolar extraction space that will be performed on intervention sides according to a standardized protocol
Device: low intensity pulsed ultrasound and iPRF
LIPUS side:closure of premolar extraction space control side
closure ofpremolar extraction space that will be performed with iPRFapplication according to a standardized protocol
Device: low intensity pulsed ultrasound and iPRF
iPRF side canine retraction control side wihout intervention
distalization assisted with LIPUS according to a standardized protocol
Device: low intensity pulsed ultrasound and iPRF
distalization without LIPUS intervention
distalization will be commenced with application of iPRF according to a standardized protocol
Device: low intensity pulsed ultrasound and iPRF
distalization will be commenced without application of LLLT according to a standardized protocol
leveling and alignment assisted with LIPUS according to a standardized protocol
Device: low intensity pulsed ultrasound and iPRF
leveling and alignment be commenced with application of iPRF according to a standardized protocol
Device: low intensity pulsed ultrasound and iPRF
leveling and alignment without intervention
intrusion assisted with LIPUS according to a standardized protocol
Device: low intensity pulsed ultrasound and iPRF
intrusion assisted with application of iPRF according to a standardized protocol
Device: low intensity pulsed ultrasound and iPRF
intrusion without intervention
iPRF and LIPUS has been found to speed up OTM by stimulating the RANK/RANKL/OPG system to initiate osteoclast formation.
Also known as: injectaleplatelets rich fibrin
Influence of low-level laser therapy versus low-intensity pulsed ultrasound on rate of different orthodontic tooth movements by millimeter
rate of orthodontic tooth movement by millimeter
Time frame: post interventionalal at 6months
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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Al-Azhar University