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RecruitingNCT06251479OMNIBUS2023Updated Mar 31, 2026

Study of the Dynamics of Verbal and Non-verbal Interaction in Healthy Subjects, Through the Recording of Body Movements and Non-invasive Neurophysiological Techniques

An interventional study of behavioral 1 and behavioral 2 in Neuroscience and Neuromodulation, sponsored by IRCCS Centro Neurolesi Bonino Pulejo. Recruiting at 1 site in Italy. Open to participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-31.

Sponsored by IRCCS Centro Neurolesi Bonino Pulejo · Not applicable, Interventional, and Screening

Phase
Not applicable
Study type
Interventional
Enrollment
200
Allocation
Randomized
Ages
18 Years to 55 Years
Sex
All
01

Study summary

Based on study literature, the investigators can say that our study aims to give an explanation not only from a behavioral point of view but also with respect to what are the neuronal mechanisms underlying our ability to perceive and analyze our own and others' actions. This is essential to fully understand the complexity of our social behaviors. The knowledge of these mechanisms has a high value and relevant implications for many research fields both within and outside the neurosciences. The project aims to study the neurobehavioral correlates of verbal and non-verbal communication. Through the use of non-invasive behavioral and neurophysiological techniques, the study intends to highlight the neurobehavioral markers that allow to quantify the temporal evolution of communication dynamics in healthy subjects.

Read the detailed description

Based on study literature, the investigators can say that our study aims to give an explanation not only from a behavioral point of view but also with respect to what are the neuronal mechanisms underlying our ability to perceive and analyze our own and others' actions. This is essential to fully understand the complexity of our social behaviors. The knowledge of these mechanisms has a high value and relevant implications for many research fields both within and outside the neurosciences. The project aims to study the neurobehavioral correlates of verbal and non-verbal communication. Through the use of non-invasive behavioral and neurophysiological techniques, the study intends to highlight the neurobehavioral markers that allow to quantify the temporal evolution of communication dynamics in healthy subjects.

  1. the investigators intend to verify whether individual differences in the ability to discriminate the verbal and non-verbal signals of others are reflected in significant differences in the way the same actions are performed.
  2. the investigators intend to quantify the behavioral variables during the execution of the action and observe how these are modified in the passage from a single execution to an interaction context.
  3. the investigators intend to study how the interactive context influences the cerebral and cortico-muscular oscillatory dynamics during the preparation of the action.
  4. the investigators intend to verify whether the activity of the motor system contributes not only to the execution of the action but also, if and, if so, to the perception of the actions of others
02

Conditions studied

  • Neuroscience
  • Neuromodulation
03

Who can participate

Ages eligible
18 Years to 55 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Age range between 18 and 55 years
  • written informed consent
  • healthy subjects

Exclusion criteria

Exclusion Criteria:

  • epilepsy or at risk of epileptic seizures,
  • cardiac pacemaker wearers,
  • presence of an implanted infusion pump,
  • metal plaques in the skull or metal objects in the eye and skull taking neuroleptic drugs or tricyclic antidepressants,
  • migraine or at risk of developing this disease.
04

Study design

Phase
Not applicable
Primary purpose
Screening
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
200 participants (estimated)

Study arms

  • Experimental
    A group behavioral 1

    The first group will perform perceptual and verbal and non-verbal motor execution tasks, while behavioral measurement techniques will be used.

    Behavioral: behavioral 1

  • Experimental
    B group behavioral 2

    The second group will perform the same tasks as group A and will be subjected to the same measurements as group A. Differently from group A, the members of group B will perform the experimental tasks together with another participant.

    Behavioral: behavioral 2

  • Experimental
    C group neuromoulation 1

    The third group is identical to group A except that neurophysiological measurement techniques will also be applied.

    Device: neuromodulation 1

  • Experimental
    D group neuromodulation 2

    The fourth group is identical to group B except that neurophysiological measurement techniques will also be applied.

    Device: neuromodulation 2

Interventions

  • Behavioralbehavioral 1

    verbal and non verbal tasks

  • Behavioralbehavioral 2

    verbal and non verbal tasks with other partecipants

  • Deviceneuromodulation 1

    registration with neurophysiological tecniques during verbal and non verbal tasks

  • Deviceneuromodulation 2

    registration with neurophysiological tecniques during verbal and non verbal tasks with other partecipants

05

What researchers measure

Primary outcomes

  1. Embodiment Scale

    patients have to experience rubber hand illusion first with a silicon and and second with a robotic hand. the embodiment variance is evaluted in the two condition with the embofiment scale

    Time frame: 1 hour

Secondary outcomes

  1. Embodiment Scale

    patients have to experience with a single-pulse Transcranial magnetic stimulation during seeing a visual cue where a human hand is stung. the questionnaire evalute the embodiment variance

    Time frame: 1 hour

06

Study locations

1 of 1 sites recruiting
  • IRCCS Centro Neurolesi Bonino Pulejo
    Messina, Messina 98124, Italy
    Recruiting
07

Registry details

Key details

Study ID
NCT06251479
Lead sponsor
IRCCS Centro Neurolesi Bonino Pulejo
Responsible party
Caterina Formica (Caterina Formica, PhD, PSY, IRCCS Centro Neurolesi Bonino Pulejo) — Principal investigator
First posted
Feb 9, 2024
Start date
Aug 16, 2023
Primary completion
Dec 28, 2023
Completion
Aug 16, 2026 (estimated)
Last update
Mar 31, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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