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RecruitingNCT06233539Updated Apr 3, 2024

A Study on Diagnosis and Treatment Strategies for Atlantoaxial Dislocation

An observational study in Atlantoaxial Dislocation, Treatment and Diagnostic, sponsored by Peking University Third Hospital. Recruiting at 1 site in China. Per ClinicalTrials.gov, last updated 2024-04-03.

Primary conditionnone(registry's first term: Disease)No conditionIs this wrong?Disease describes something many studies share rather than a condition a study is about. The study names no condition we can place it under, so it is not compared with other studies by condition.

Sponsored by Peking University Third Hospital · Observational

From the registry’s dates

  • Primary completion was expected by Dec 2025, 10 months ago, but the record still lists the study as recruiting.
  • Started Dec 2022; still recruiting 3 years 11 months later.
Study type
Observational
Model
Cohort
Time perspective
Other
Enrollment
3,000
Sex
All
01

Study summary

The most effective treatment for atlantoaxial dislocation is surgical treatment, with the principle of achieving reduction, reconstruction, and fusion of the atlantoaxial joint. The surgical strategies mainly include simple anterior approach, simple posterior approach, and combined anterior posterior approach. The investigators have summarized 904 cases of atlantoaxial instability or dislocation from 1998 to 2010 and preliminarily published the diagnosis and treatment strategy tree of the Third Hospital of Beijing Medical University. This strategy is divided into four types based on the severity of atlantoaxial dislocation: unstable, reversible, difficult to recover, and skeletal, and enters different surgical treatment processes. With the increase in the number of cases, accumulation of experience, and technological improvements in the past decade, spinal surgery colleagues have updated their classification diagnosis, diagnosis and treatment processes, and surgical techniques for atlantoaxial instability or dislocation.

However, the selection of treatment strategies for atlantoaxial dislocation is mostly based on the surgeon's own experience, and there is a lack of standardized, large-scale, and high-level evidence-based medical research on the safety and effectiveness of current empirical strategies. Based on this, this study intends to adopt a multicenter, retrospective, and prospective study to construct a high-quality clinical cohort of atlantoaxial dislocation, update the classification and diagnosis and treatment strategies of atlantoaxial dislocation. And conduct long-term follow-up on patients to evaluate their safety and effectiveness, guide the surgical treatment of atlantoaxial dislocation, and thus form a recognized diagnostic and treatment standard for atlantoaxial dislocation.

02

Conditions studied

  • Atlantoaxial Dislocation
  • Treatment
  • Diagnostic

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03

In context

Lead sponsor

Peking University Third Hospital is the lead sponsor of 752 studies on the registry; 273 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients diagnosed with atlantoaxial dislocation and treated with surgery

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Inclusion criteria

  • Patients diagnosed with atlantoaxial dislocation and treated with surgery

Exclusion criteria

Exclusion Criteria:

  • Disagree to participate in this study.
05

Study design

Observational model
Cohort
Time perspective
Other
Enrollment
3,000 participants (estimated)
Target follow-up
1 Year
Patient registry
Yes

Groups and cohorts

  • Retrospective section

    Other: Observational research without intervention

  • Prospective section

    Other: Observational research without intervention

Interventions

  • OtherObservational research without intervention

    Observational research without intervention

06

What researchers measure

Primary outcomes

  1. The incidence of special attention adverse events in patients within 12 months after surgery

    The proportion of adverse events occurring in patients during the study period to the total number of study patients. Recording and reporting of adverse events, including: • deterioration of neurological function * Incision infection * Vascular injury Airway obstruction Poor reset • Unplanned readmission and unplanned reoperation • Internal fixation failure Fusion failure Surgical related lower cervical spine deformities

    Time frame: 12 month follow up

07

Study locations

1 of 1 sites recruiting
  • Shenglin Wang
    Beijing, Beijing 100191, China
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 3, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06233539
Responsible party
Sponsor
First posted
Jan 31, 2024
Start date
Dec 1, 2022
Primary completion
Dec 31, 2025 (estimated)
Completion
Dec 31, 2026 (estimated)
Last update
Apr 3, 2024

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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