An interventional study of Raman microspectroscopy in Chronic Ankle Instability, sponsored by GCS Ramsay Santé pour l'Enseignement et la Recherche. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-04-06.
Sponsored by GCS Ramsay Santé pour l'Enseignement et la Recherche · Not applicable, Interventional, and Treatment
A population of patients with chronic ankle instability for whom arthroscopic ligament stabilisation was indicated.
Main objective: to use the Raman microspectroscopy technique to characterise the synovial fluid of the unstable ankle in comparison with the synovial fluid of the healthy ankle.
Single-centre, prospective, open-label study of patients undergoing ankle stabilisation surgery.
Patients will participate in the study for six months. Three arthrocentheses with synovial fluid sampling will be performed Two at D0: on the healthy ankle and the pathological ankle One at M6: on the operated ankle A follow-up visit will take place 10 days after the arthrocentesis performed at D0 and after the one performed at M6. The purpose of these visits, which are carried out systematically by the centre's doctors as part of the surgical procedures, is to check that there are no complications.
GCS Ramsay Santé pour l'Enseignement et la Recherche is the lead sponsor of 198 studies on the registry; 94 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Unstable ankle
Other: Raman microspectroscopy
Other: Raman microspectroscopy
Raman microspectroscopy is a non-destructive method for observing and characterising the molecular composition and external structure of a biological sample based on the phenomenon of inelastic light scattering (Raman effect).
Spectral intensity of synovial fluid components
Spectral intensity of synovial fluid components : Raman microspectroscopy is a non-destructive method for observing and characterising the molecular composition and external structure of a biological sample based on the phenomenon of inelastic light scattering. Four regions of interest (ROIs) are defined at the four cardinal points in the peripheral zone where the pre-concentration of solutes is maximal. Six points are mapped in each ROI. Each drop is thus defined by 4 x 6 points, making it possible to check intra- and inter-ROI homogeneity. Spectral acquisitions were carried out after illumination by a laser source. The mean spectrum of each LS drop is defined as the average of the four mean spectra of the ROIs, originating from the four cardinal points of the drop. The component Raman bands are identified and assigned on the basis of bibliographic data.
Time frame: Month 6
Functional criterion (American Orthopaedic Foot and Ankle Society-AOFAS score)
Functional criterion (AOFAS score)
Time frame: Month 6
Tribological criteria (drop surface measurement)
Tribological criteria (drop surface measurement)
Time frame: Month 6
Tribological criteria (drop thickness measurement)
Tribological criteria (drop thickness measurement)
Time frame: Month 6
This study is completed, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.
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GCS Ramsay Santé pour l'Enseignement et la Recherche